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Review
. 2022 May;24(5):757-769.
doi: 10.1007/s12094-021-02734-2. Epub 2021 Nov 28.

Cancer-associated fibroblasts in colorectal cancer

S Kamali Zonouzi  1   2 , P S Pezeshki  1   2 , S Razi  2   3 , N Rezaei  4   5   6
Affiliations
Review

Cancer-associated fibroblasts in colorectal cancer

S Kamali Zonouzi et al. Clin Transl Oncol. 2022 May.

Abstract

Colorectal cancer (CRC) is one of the leading causes of mortality among cancers. Many aspects of this cancer are under investigation to find established markers of diagnosis, prognosis, and also potential drug targets. In this review article, we are going to discuss the possible solution to all these aims by investigating the literature about cancer-associated fibroblasts (CAFs) involved in CRC. Moreover, we are going to review their interaction with the tumor microenvironment (TME) and vitamin D and their role in tumorigenesis and metastasis. Moreover, we are going to expand more on some markers produced by them or related to them including FAP, a-SMA, CXCL12, TGF- β, POSTN, and β1-Integrin. Some signaling pathways related to CAFs are as follows: FAK, AKT, activin A, and YAP/TAZ. Some genes related to the CAFs which are found to be possible therapeutic targets include COL3A1, JAM3, AEBP1 and, CAF-derived TGFB3, WNT2, and WNT54.

Keywords: Cancer-associated fibroblast; Colorectal cancer; Diagnosis; Prognosis; Treatment; Tumorigenesis.

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References

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