Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;46(6):444-453.
doi: 10.30476/ijms.2020.85872.1550.

Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients

Shaghayegh Mottaghi  1 , Mohammad Mahdi Sagheb  2 , Negar Azarpira  3 , Faezeh Abdizadeh  1 , Romina Faeghi  1 , Iman Karimzadeh  1
Affiliations

Association between the Three Polymorphisms of the Glucocorticoid Receptor Gene and the Early Clinical Outcome in Kidney Transplantation Patients

Shaghayegh Mottaghi et al. Iran J Med Sci. 2021 Nov.

Abstract

Background: Glucocorticoids are pivotal components of immunosuppressive regimens in solid organ transplantations. This study aimed to assess the possible association between the ER22/23EK, N363S, and Bcl1 polymorphisms, and short-term clinical outcomes, including acute rejection and delayed graft function (DGF), in kidney transplantation recipients.

Methods: A case-control study was conducted in a two-year period on adults with transplanted kidneys, comprised of subjects without rejection (n=50, control) and those with documented rejection within one year after transplantation (n=50, case), between April 2017 and September 2018, in Shiraz, Iran. Demographic characteristics and clinical and paraclinical findings were gathered. The genotyping of the ER22/23EK, N363S, and Bcl1 polymorphisms was carried out via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The association between the genotypes and DGF as well as rejection types was evaluated using either the Chi square test or Fisher exact test. A stepwise logistic regression analysis was conducted to determine the independent factors of acute rejection within the first year after transplantation.

Results: The study population consisted of 64 men and 36 women. The frequency of mutated alleles was 0.32 for G (Bcl1), 0.02 for S (N363S), and 0.065 for A (ER22/23EK). There was no significant association either between the studied polymorphisms and acute rejection or between the Bcl1 (P=0.17), N363S (P=0.99), and ER22/23EK (P=0.99) genotypes and DGF. The length of hospital stay after kidney transplantation was slightly more in N363N and ER22/23EK wild allele carriers. However, this difference was not statistically significant.

Conclusion: Our data suggested no statistically significant association between the genotypes of the studied polymorphisms and early clinical outcomes after kidney transplantation.

Keywords: Genetic; Glucocorticoids; Kidney transplantation; Polymorphism; Receptors.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Diwan V, Brown L, Gobe GC. Adenine-induced chronic kidney disease in rats. Nephrology (Carlton) 2018;23:5–11. doi: 10.1111/nep.13180. - DOI - PubMed
    1. Tabriziani H, Lipkowitz MS, Vuong N. Chronic kidney disease, kidney transplantation and oxidative stress: a new look to successful kidney transplantation. Clin Kidney J. 2018;11:130–5. doi: 10.1093/ckj/sfx091. [ PMC Free Article ] - DOI - PMC - PubMed
    1. Einollahi B. Kidney transplantation in Iran. Iranian Journal of Medical Sciences. 2010;35:1–8.
    1. Sharing UNfO [Internet] Transplant Trends: United Network for Organ Sharing. [cited 2019 Oct 11] Available from: https://unos.org/data/transplant-trends/
    1. nternational registry in organ donation and transplantation [Internet] [cited 31 May 2020]. Available from: https://www.irodat.org/?p=database&c=IR&year=2019#data .

Publication types