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. 2021 Nov 19:2021:4434504.
doi: 10.1155/2021/4434504. eCollection 2021.

Study of the Therapeutic Effects of Chinese Herbal Decoction Combined with Glucocorticoid in Treating Primary Nephrotic Syndrome in Children

Xue Hou  1 , Meihua Xu  2 , Jie Li  3 , Rui Li  4 , Jinzhi Zhang  5 , Jing Ju  6
Affiliations

Study of the Therapeutic Effects of Chinese Herbal Decoction Combined with Glucocorticoid in Treating Primary Nephrotic Syndrome in Children

Xue Hou et al. Evid Based Complement Alternat Med. .

Abstract

Background: To investigate the clinical effects of Chinese medicine decoction combined with glucocorticoid in treating children with primary nephrotic syndrome.

Methods: A total of 70 children with pediatric nephritis nephrotic syndrome treated at Weifang People's Hospital from January 2019 to December 2019 were randomly allocated to the therapy group and the control group, each with 35 cases. The control group was treated with conventional Western medicine, and the therapy group received Western medicine and Chinese medicine. After 12 weeks of treatment, the therapeutic effect of the two groups was compared.

Results: After receiving the treatment, the levels of urine protein (UPro), triglyceride, and cholesterol were significantly decreased in the two groups (p < 0.05), and these levels in the therapy group were much lower than those of the control group (p < 0.05). However, the level of albumin (ALB) was predominantly increased in the two groups after treatment (p < 0.05), and this level in the therapy group was much higher than that of the control group (p < 0.05). Moreover, the immune indicators, coagulation function, and recurrence rate were noticeably improved after treatment (p < 0.05), and the therapy group was better than the control group (p < 0.05). Furthermore, the comparison of renal function indexes, liver function indexes, and blood routine between the two groups showed no statistical significance in the incidence of adverse reactions between the two groups (p > 0.05).

Conclusions: For the treatment of refractory nephrotic syndrome in children, based on conventional shock therapy, the addition of traditional Chinese medicine (Liuwei Dihuang pill decoction) remedy can significantly improve the disease symptoms in children and improve the efficacy, and the incidence of adverse reactions is low.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
General conditions before treatment. (a) The gender distribution in the control group and therapy group. (b) The age distribution in the control group and therapy group. (c) The length of disease distribution in the control group and therapy group.
Figure 2
Figure 2
Comparison of cellular immunoassay between the two groups before and after treatment.
Figure 3
Figure 3
Comparison of humoral immune indexes before and after treatment between the two groups.
Figure 4
Figure 4
Comparison of changes in liver function between the two groups (μ/L).
Figure 5
Figure 5
Comparison of blood routine between the two groups.
See this image and copyright information in PMC

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