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Review
. 2021 Oct;11(5):438-444.
doi: 10.1212/CPJ.0000000000001009.

Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus

Neha Kaul  1 , Joshua Laing  1 , John-Paul Nicolo  1 , Judy Nation  1 , Patrick Kwan  1 , Terence J O'Brien  1
Affiliations
Review

Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus

Neha Kaul et al. Neurol Clin Pract. 2021 Oct.

Abstract

Purpose of review: Ketogenic diet therapy can be used as an adjuvant treatment of super-refractory status epilepticus (SRSE). However, the drug and metabolic interactions with concomitant treatments present a challenge for clinicians. In this review, we focus on the practical considerations of implementing ketogenic dietary therapy in the acute setting, including the dietary composition, potential drug-diet interactions, and monitoring during ketogenic treatment.

Recent findings: This report describes the ketogenic diet therapy protocol implemented for the treatment of SRSE and a review of the current evidence to support clinical practice.

Summary: The control of SRSE is critical in reducing morbidity and mortality. There is emerging evidence that ketogenic diet may be a safe and effective treatment option for these patients.

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Figures

Figure
Figure. Proposed Mechanisms of Action of the Ketogenic Diet,,43–46
GABA = gamma-aminobutyric acid; GG = gamma-glutamylated.
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References

    1. Treatment of convulsive status epilepticus: recommendations of the Epilepsy Foundation of America's Working Group on status epilepticus. JAMA 1993;270:854–859. - PubMed
    1. Glauser T, Shinnar S, Gloss D, et al. . Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr 2016;16:48–61. - PMC - PubMed
    1. Shorvon S, Ferlisi M. The outcome of therapies in refractory and superrefractory convulsive status epilepticus and recommendations for therapy. Brain 2012;135:2314–2328. - PubMed
    1. Fountain NB. Status epilepticus: risk factors and complications. Epilepsia 2000;41:S23–S30. - PubMed
    1. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain 2011;134:2802–2818. - PubMed