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Review
. 2021 Oct;11(5):438-444.
doi: 10.1212/CPJ.0000000000001009.

Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus

Neha Kaul  1 , Joshua Laing  1 , John-Paul Nicolo  1 , Judy Nation  1 , Patrick Kwan  1 , Terence J O'Brien  1
Affiliations
Review

Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus

Neha Kaul et al. Neurol Clin Pract. 2021 Oct.

Abstract

Purpose of review: Ketogenic diet therapy can be used as an adjuvant treatment of super-refractory status epilepticus (SRSE). However, the drug and metabolic interactions with concomitant treatments present a challenge for clinicians. In this review, we focus on the practical considerations of implementing ketogenic dietary therapy in the acute setting, including the dietary composition, potential drug-diet interactions, and monitoring during ketogenic treatment.

Recent findings: This report describes the ketogenic diet therapy protocol implemented for the treatment of SRSE and a review of the current evidence to support clinical practice.

Summary: The control of SRSE is critical in reducing morbidity and mortality. There is emerging evidence that ketogenic diet may be a safe and effective treatment option for these patients.

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Figures

Figure
Figure. Proposed Mechanisms of Action of the Ketogenic Diet,,43–46
GABA = gamma-aminobutyric acid; GG = gamma-glutamylated.
See this image and copyright information in PMC

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