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Review
. 2021 Nov 25;37(11):3880-3889.
doi: 10.13345/j.cjb.210040.

[Advances of Cas9/sgRNA delivery system for gene editing]

[Article in Chinese]
Xuan Hu  1   2 , Song Wang  1 , Lu Yu  2 , Xiaopeng Zhang  2 , Wei Chen  2
Affiliations
Free article
Review

[Advances of Cas9/sgRNA delivery system for gene editing]

[Article in Chinese]
Xuan Hu et al. Sheng Wu Gong Cheng Xue Bao. .
Free article

Abstract

In the application of CRISPR genome editing, direct cellular delivery of non-replicable Cas9/sgRNA may reduce unwanted gene targeting and integrational mutagenesis, thus offering greater specificity and safety. Cas9/sgRNA delivery system holds great potential for treating genetic diseases. This review summarizes the advances of Cas9/sgRNA delivery systems and its therapeutic applications, providing new understandings and inspirations for vector design and future clinical applications.

Keywords: Cas9/sgRNA delivery; gene editing; genetic therapy; nanocarrier.

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