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. 2021 Nov 1;24(11):788-795.
doi: 10.34172/aim.2021.118.

Isfahan Thyroid Cohort Study (ITCS)

Samaneh Shahrokh Esfahani  1 , Aliye Tabatabaee  1 , Ashraf Aminorroaya  1 , Masoud Amini  1 , Awat Feizi  2 , Mohsen Janghorbani  1 , Azamosadat Tabatabaei  1 , Rokhsareh Meamar  3 , Atoosa Adibi  1 , Majid Abyar  1 , Mozhgan Karimifar  1 , Raheleh Sajad  1 , Rezvan Salehidoost  1 , Elham Faghih Imani  1 , Silva Hovsepian  1 , Mehri Sirous  4 , Sima Aminorroaya Yamini  5
Affiliations
Free article

Isfahan Thyroid Cohort Study (ITCS)

Samaneh Shahrokh Esfahani et al. Arch Iran Med. .
Free article

Abstract

Background: The Isfahan Thyroid Cohort Study (ITCS) is one of the few population-based epidemiological studies in Iran that investigates the prevalence and incidence of thyroid disorders including hypothyroidism, hyperthyroidism, goiter, nodule, and iodine status.

Methods: This cohort is located in Isfahan, Iran. The first phase was initiated in 2006 with 2523 participants (1275 males, 1248 females). The participants were selected using multi-stage cluster sampling from the general residents of Isfahan, Iran. The study had two phases (2006 and 2011) and its third stage is planned for 2020-2021.

Results: The prevalence of thyroid function states was euthyroid (89.3%, 95% CI: 88%-90%), overt hypothyroidism (2.8%, 95% CI: 2%‒3%), subclinical hypothyroidism (5.8%, 95% CI: 4%-6%), overt hyperthyroidism (0.8%, 95% CI: 0.4%‒1%), and subclinical hyperthyroidism (0.99%, 95% CI: 0.6%-1%). Hypothyroidism and hyperthyroidism were significantly associated with goiter. The incidence of thyroid dysfunction was reported as follows: overt hypothyroidism (2.7, 95% CI: 1.6-3.7), subclinical hypothyroidism (20.6, 95% CI: 18-23), overt hyperthyroidism (1.9, 95% CI: 1-2.7) and subclinical hyperthyroidism (2.7, 95% CI: 1.6-3.7) per 1000 (person-year).

Conclusion: We assessed the prevalence and incidence of thyroid disorders in Isfahan in the first and second phase, respectively. We are conducting the third phase of the ITCS in order to study the associations between thyroid peroxidase antibody (TPOAb) level and environmental factors such as infection.

Keywords: Cohort studies; Goiter; Hyperthyroidism; Hypothyroidism.

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