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Case Reports
. 2021 Nov 23;13(4):624-631.
doi: 10.3390/pediatric13040074.

Ivabradine-Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review

Giovanni Maria Di Marco  1 , Angelica De Nigris  2 , Angela Pepe  3 , Annamaria Pagano  4 , Giangiacomo Di Nardo  1 , Vincenzo Tipo  5
Affiliations
Case Reports

Ivabradine-Flecainide as Breakthrough Drug Combination for Congenital Junctional Ectopic Tachycardia: A Case Report and Literature Review

Giovanni Maria Di Marco et al. Pediatr Rep. .

Abstract

Congenital junctional ectopic tachycardia (CJET) is a rare tachyarrhythmia that remains difficult to manage, with suboptimal control in most cases. Here, we report literature research on the use of ivabradine in the treatment of pediatric junctional ectopic tachycardia (JET), both congenital and postoperative, and describe the successful use of ivabradine-flecainide association for CJET therapy resistant to other antiarrhythmic agents. This new drug combination was effective in completely suppressing JET. Ivabradine-flecainide combination may be considered a new therapeutic strategy of CJET with a satisfactory efficacy/tolerability ratio in patients resistant to conventional drug combinations.

Keywords: congenital; ivabradine; junctional; pediatrics; tachycardia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
JET at diagnosis.
Figure 2
Figure 2
Restoration of sinus rhythm in patient with JET treated with ivabradine in combination with flecainide.
Figure 3
Figure 3
CJET management in our case, step by step.
See this image and copyright information in PMC

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