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Review
. 2021 Oct 27;6(4):192.
doi: 10.3390/tropicalmed6040192.

Systemic, Mucosal, and Memory Immune Responses following Cholera

Edward T Ryan  1   2   3 , Daniel T Leung  4 , Owen Jensen  4 , Ana A Weil  5 , Taufiqur Rahman Bhuiyan  6 , Ashraful Islam Khan  6 , Fahima Chowdhury  6 , Regina C LaRocque  1   2 , Jason B Harris  1   7   8   9 , Stephen B Calderwood  1   2   10 , Firdausi Qadri  6 , Richelle C Charles  1   2   3
Affiliations
Review

Systemic, Mucosal, and Memory Immune Responses following Cholera

Edward T Ryan et al. Trop Med Infect Dis. .

Abstract

Vibrio cholerae O1, the major causative agent of cholera, remains a significant public health threat. Although there are available vaccines for cholera, the protection provided by killed whole-cell cholera vaccines in young children is poor. An obstacle to the development of improved cholera vaccines is the need for a better understanding of the primary mechanisms of cholera immunity and identification of improved correlates of protection. Considerable progress has been made over the last decade in understanding the adaptive and innate immune responses to cholera disease as well as V. cholerae infection. This review will assess what is currently known about the systemic, mucosal, memory, and innate immune responses to clinical cholera, as well as recent advances in our understanding of the mechanisms and correlates of protection against V. cholerae O1 infection.

Keywords: Vibrio cholerae; adaptive; antibody; cellular; cholera; immunity; innate; memory; mucosal; systemic; vaccine.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the interpretation of prior studies, the writing of the manuscript, or in the decision of which manuscripts to include in this review.

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