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Review
. 2021 Dec;18(6):538-548.
doi: 10.1007/s11904-021-00582-x. Epub 2021 Nov 29.

Central Nervous System Effects of COVID-19 in People with HIV Infection

Michael J Peluso  1 , Joanna Hellmuth  2 , Felicia C Chow  3   4
Affiliations
Review

Central Nervous System Effects of COVID-19 in People with HIV Infection

Michael J Peluso et al. Curr HIV/AIDS Rep. 2021 Dec.

Abstract

The convergence of the HIV and SARS-CoV-2 pandemics is an emerging field of interest. In this review, we outline the central nervous system (CNS) effects of COVID-19 in the general population and how these effects may manifest in people with HIV (PWH). We discuss the hypothetical mechanisms through which SARS-CoV-2 could impact the CNS during both the acute and recovery phases of infection and the potential selective vulnerability of PWH to these effects as a result of epidemiologic, clinical, and biologic factors. Finally, we define key research questions and considerations for the investigation of CNS sequelae of COVID-19 in PWH.

Keywords: COVID-19; Central nervous system; HIV; SARS-CoV-2.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Summary of the potential overlap between known or suspected mechanisms underlying central nervous system manifestations of SARS-CoV-2 and HIV infection
See this image and copyright information in PMC

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