An overview and bibliometric analysis on the colorectal cancer therapy by magnetic functionalized nanoparticles for the responsive and targeted drug delivery

Abstract

With the growing demands for personalized medicine and medical devices, nanomedicine is a modern scientific field, and research continues to apply nanomaterials for therapeutic and damaged tissue diagnosis. In this regard, substantial progress has been made in synthesizing magnetic nanoparticles with desired sizes, chemical composition, morphologies, and surface chemistry. Among these materials, nanomagnetic iron oxides have demonstrated promise as unique drug delivery carriers due to cancer treatment. This carrier could lead to responsive properties to a specific trigger, including heat, pH, alternative magnetic field, or even enzymes, through functionalization and coating of magnetic nanoparticles, along with biocompatibility, good chemical stability, easy functionalization, simple processing, and ability to localize to the tumor site with the assistance of external magnetic field. Current studies have focused on magnetic nanoparticles' utilities in cancer therapy, especially for colorectal cancer. Additionally, a bibliometric investigation was performed on the public trends in the field of the magnetic nanoparticle to drug delivery and anticancer, which represented progressing applications of these carriers in the multidisciplinary zones with a general view on future research and identified potential opportunities and challenges. Furthermore, we outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment.

Keywords: Anticancer drugs; Bibliometric analysis; Colon cancer; Drug-delivery; Magnetic nanoparticles.

Fig. 1

Use of Magnetic nanoparticles in medicine

Fig. 2

Prisma flow diagram

Fig. 3

a The network of keywords and b clustering of keywords during the time period

Fig. 4

a Country collaboration map-related documents-published in the considered period, b three-field plot of top-author, top-countries; and top authors keywords on the considered topic

Fig. 5

The most relevant affiliations on the considered topic

Fig. 6

The most cited countries on considered topic, inset: the bibliometric analysis by subject area

Fig. 7

a The plot of world growth of considered topic based on the subject, and b annual scientific publications sorted by publication years

Fig. 8

Drug loading process on the magnetic NPs, stimuli sensitive release of drugs upon applying external stimuli and schematic illustration description the in vivo and in vitro nano combination therapy

Fig. 9

Structure of 3 most common anticancer drugs 5-fluorouracil (5-FU), oxaliplatin, and irinotecan for colon cancer by magnetic nanoparticles

Fig. 10

The timeline of magnetic nanoparticles in therapeutic and imaging application

Fig. 11

Drug loading and sensitive release of drugs upon applying external stimuli

Fig. 12

The schematic of prodrug 5-FC in drug delivery based on magnetic nanocarrier

Fig. 13

The schematic representation of tumor treatment through stimuli sensitive release of drugs by magnetic nanocarrier and in vivo and in vitro