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Comment
. 2022 Jan;28(1):5-7.
doi: 10.1016/j.molmed.2021.11.002. Epub 2021 Nov 26.

Targeting ACC for NASH resolution

Xiao-Jing Zhang  1 , Jingjing Cai  2 , Hongliang Li  3
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Comment

Targeting ACC for NASH resolution

Xiao-Jing Zhang et al. Trends Mol Med. 2022 Jan.

Abstract

A recent paper published in Nature Medicine by Calle et al. reported anti-nonalcoholic steatohepatitis (NASH) efficiencies by acetyl-CoA carboxylase (ACC) 1/2 inhibitors alone or by co-administration with a ACC1/2 inhibitor and a diacylglycerol acyltransferase 2 (DGAT2) inhibitor. Whereas the monotherapy achieved remarkable reductions in liver steatosis but induced hyperlipidemia, DGAT2 inhibitor co-administration mitigated the increase in serum triglycerides (TGs).

Keywords: ACC; DGAT2; NASH; hepatic steatosis; hypertriglyceridemia.

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