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Review
. 2022 Apr 1;34(2):57-61.
doi: 10.1097/GCO.0000000000000765.

Cellular aging and telomere dynamics in pregnancy

Danielle M Panelli  1 , Katherine Bianco
Affiliations
Review

Cellular aging and telomere dynamics in pregnancy

Danielle M Panelli et al. Curr Opin Obstet Gynecol. .

Abstract

Purpose of review: Telomere biology is an emerging area of scientific interest. Telomeres are deoxynucleic acid caps at the ends of chromosomes that naturally shorten over one's lifespan; because of this, short telomeres have been studied as a marker of cellular aging. Given the association between short telomeres and genetic and environmental factors, their role in pregnancy has become an intriguing area of research.

Recent findings: This review describes recent data on telomeres in pregnancy. Specifically, we discuss the association between short maternal leukocyte telomeres and poor nutritional status, between short neonatal telomeres and greater maternal psychosocial stress, and between shorter fetal amniotic membrane telomeres and the spontaneous onset of parturition. We also review recent studies suggesting that events during pregnancy can impact telomeres in the offspring years into the future.

Summary: Telomere length varies in maternal, placental, and neonatal cells, but within each of these compartments telomeres may play their own distinct role during pregnancy. Whether telomeres are reflective of the cumulative impact of stressors, or part of an as-yet unknown fetal programming mechanism is an area of interest. With future research, we may work toward a better understanding of gestational biology which could have far reaching intergenerational impacts.

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Conflict of interest statement

2: Conflicts of interest: None

References

    1. Notterman DA, Schneper L. Telomere Time-Why We Should Treat Biological Age Cautiously. JAMA Netw open. 2020;3(5):e204352. doi: 10.1001/jamanetworkopen.2020.4352

      * This article reviews the nuance of studying telomeres as a biological clock.

    1. Vaiserman A, Krasnienkov D. Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives. Front Genet. 2021;11(January). doi: 10.3389/fgene.2020.630186

      ** This is a thorough, contemporary review of telomere biology that thoughtfully interrogates recent findings in telomere research. It concludes that telomeres would be a useful addition to cellular aging composits, but highlights important limitations for use of telomeres as a single biomarker that need to be considered in future research.

    1. Shalev I, Entringer S, Wadhwa PD, et al. Stress and telomere biology: A lifespan perspective. Psychoneuroendocrinology. 2013;38(9):1835–1842. 10.1016/j.psyneuen.2013.03.010

      ** This landmark review presents hypotheses regarding fetal programming of telomere biology and its consequences across the lifespan of the child. It also links evidence from childhood trauma and poor mental health with accelerated telomere shortening, and sets up future research in this area.

    1. Müezzinler A, Zaineddin AK, Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing Res Rev. 2013;12(2):509–519.

      * This systematic review demonstrates available evidence correlating leukocyte telomere length with chronologic age, which has been shown to be the strongest predictor of telomere shortening.

    1. Demanelis K, Jasmine F, Chen LS, et al. Determinants of telomere length across human tissues. Science. 2020;369(6509). doi: 10.1126/SCIENCE.AAZ6876

      * This study reports variability in telomere length across different tissue types, and showed that while telomeres vary by tissue, they shorten with age in the majority of tissues sampled.

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