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. 2022 Mar;198(3):268-281.
doi: 10.1007/s00066-021-01877-z. Epub 2021 Nov 29.

Clinical relevance of the timing of radiotherapy after breast-conserving surgery : Results of a large, single-centre, population-based cohort study

Jan J Jobsen  1   2 , Henk Struikmans  3 , Job van der Palen  4   5 , Ester J M Siemerink  6
Affiliations

Clinical relevance of the timing of radiotherapy after breast-conserving surgery : Results of a large, single-centre, population-based cohort study

Jan J Jobsen et al. Strahlenther Onkol. 2022 Mar.

Abstract

Purpose: To investigate the effect of the timing of radiation therapy after breast-conserving surgery in relation to distant metastasis-free survival and disease-specific survival.

Methods: The analysis was performed in relation to 4189 women all undergoing breast-conserving therapy (BCT). Three groups were defined with respect to lymph node status and the use of adjuvant systemic therapy (AST). Patients were categorized into time intervals: < 37 days, 37-53 days, 54-112 days and > 112 days.

Results: For women without lymph node metastases and with favourable characteristics aged > 55 years, an improved treatment efficacy was noted when starting radiotherapy with a time interval of < 37 days. The same was observed for women with lymph nodes metastases receiving AST aged ≤ 50 years. Finally, for women aged > 50 years with negative lymph node status but with unfavourable characteristics and receiving AST, an improved treatment efficacy was noted when starting radiotherapy after a time interval of ≥ 37 days.

Conclusion: The results of our study further support the hypothesis that the timing of radiotherapy may have an impact on treatment efficacy and that further studies (preferably randomized trials) are indicated.

Keywords: Breast cancer; Breast-conserving therapy; Survival; Timing radiotherapy.

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References

    1. Early Breast Cancer Trialists Collaborative Group. (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patients data for 10.801 women in 17 randomised trials. Lancet 378:1707–1716 - DOI
    1. Baum M, Demicheli R, Hrushesky W, Retsky M (2005) Does surgery unfavourably pertub the natural history of early breast cancer by acceleration the appearance of distant metastases. Eur J Cancer 41:508–515 - DOI
    1. Tsoutsou PG, Koukourakis MI, Azria D, Belkacemi Y (2009) Optimal timing of radiation therapy in breast cancer. A comprehensive review and perspectives. Crit Rev Oncol Hematol 71:102–116 - DOI
    1. Huang J, Barbera L, Brouwers M, Browman G, Mackillop WJ (2003) Does delay in starting treatment affect the outcomes of radiotherapy? A systemic review. J Clin Oncol 21:555–563 - DOI
    1. Herbert-Croteau N, Freeman CR, Latreille J, Rivard M, Brisson J (2004) A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer. Breast Cancer Res Treat 88:187–196 - DOI

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