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Review
. 2022 Apr;94(4):1330-1335.
doi: 10.1002/jmv.27485. Epub 2021 Dec 7.

Host factors and vaccine efficacy: Implications for COVID-19 vaccines

Affiliations
Review

Host factors and vaccine efficacy: Implications for COVID-19 vaccines

Shahab Falahi et al. J Med Virol. 2022 Apr.

Abstract

The efficacy of the vaccines varies between individuals and populations. The immunogenicity of the vaccine is influenced by various factors, including host factors. Previous studies have shown that host factors affect the effectiveness of vaccines, which may be true about COVID-19 vaccines. In this review, we evaluate the possible association of host factors with vaccine efficacy with a special focus on COVID-19 vaccines.

Keywords: COVID-19; COVID-19 vaccine; SARS-CoV-2; host factors; vaccine efficacy; vaccine immunogenicity.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

References

    1. Lipsitch M, Dean NE. Understanding COVID‐19 vaccine efficacy. Science. 2020;370(6518):763‐765. - PubMed
    1. Slifka MK, Amanna I. How advances in immunology provide insight into improving vaccine efficacy. Vaccine. 2014;32(25):2948‐2957. - PMC - PubMed
    1. Dos Santos WG. Impact of virus genetic variability and host immunity for the success of COVID‐19 vaccines. Biomed Pharmacother. 2021;136:111272. - PMC - PubMed
    1. Falahi S, Kenarkoohi A. COVID‐19 reinfection: prolonged shedding or true reinfection? New Microbes New Infect. 2020;38:100812. - PMC - PubMed
    1. Falahi S, Kenarkoohi A. Transmission routes for SARS‐CoV‐2 infection: review of evidence. New Microbes New Infect. 2020;38:100778. - PMC - PubMed

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