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Comment
. 2022 Jan 3;219(1):e20212207.
doi: 10.1084/jem.20212207. Epub 2021 Nov 30.

Helminths make themselves at home

Elia D Tait Wojno  1
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Comment

Helminths make themselves at home

Elia D Tait Wojno. J Exp Med. .

Abstract

Drurey et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211140) show that excretory/secretory products from the parasitic helminth Heligmosomoides polygyrus suppress the host-protective small intestinal epithelial response. These findings establish that helminths directly modulate the tissue in which they live, shining new light on the host-parasite interaction.

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Helminth regulation of the host intestinal epithelium: A cost–benefit analysis. H. polygyrus produces HpES that modulates the host small intestinal epithelium in mice. HpES acts on intestinal stem cells (ISCs) to suppress tuft cell hyperplasia and cause the emergence of a fetal-like state. This modulation has potential costs and benefits for both host and parasite.
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References

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