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Case Reports
. 2021 Dec;38(12):3243-3249.
doi: 10.1007/s10815-021-02355-2. Epub 2021 Nov 30.

Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases

Ho Long Le  1   2 , Vu Ngoc Anh Ho  3   4 , Tam Thi Ngan Le  3   4 , Van Thi Thu Tran  3   4 , Mai Pham Que Ma  3   4 , Anh Hoang Le  3   4 , Linh Khanh Nguyen  3   4 , Tuong Manh Ho  3   4 , Lan Ngoc Vuong  3   4   5
Affiliations
Case Reports

Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases

Ho Long Le et al. J Assist Reprod Genet. 2021 Dec.

Abstract

Purpose: Gonadotropin-resistant ovary syndrome (GROS) is a rare endocrine disorder that causes hypergonadotropic hypogonadism, amenorrhea, and infertility. This study reports live birth in two women with GROS who underwent fertility treatment with in vitro maturation (IVM).

Methods: Both patients had primary infertility, amenorrhea (primary and secondary), typical secondary sexual characters, elevated gonadotropin levels, normal ovarian reserve, normal chromosomal characteristics, and previous nonresponsiveness gonadotropin stimulations. One patient had polymorphism of the follicle-stimulating hormone receptor, which is a predictor of poor ovarian response. Given unresponsiveness to exogenous gonadotropin stimulations, IVM with human chorionic gonadotropin priming (hCG-IVM) was performed in both patients. All transferrable embryos were vitrified.

Results: Both patients achieved pregnancy after their first frozen embryos transfer, and each delivered a healthy baby boy.

Conclusions: These results suggest that IVM should be a first-line therapeutic option for patients with GROS.

Keywords: Gonadotropin-resistant ovary syndrome; In vitro maturation; Infertility; Live birth.

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Conflict of interest statement

LNV has received speaker and conference fees from Merck; and grant, speaker, and conference fees from Merck Sharpe & Dohme and Ferring. TMH has received speaker fees from Merck, Merck Sharp & Dohme, and Ferring. All other authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Embryos for transfer: A Two day-2 embryos from patient 1; B Two day-3 embryos from patient 2
See this image and copyright information in PMC

References

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