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. 2021 Dec 1;106(12):3215-3218.
doi: 10.3324/haematol.2021.278779.

Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status

David Baker  1 , Milan Bimali  2 , Luis Carrillo  3 , Archana Sachedina  4 , Daisy Alapat  3 , Md Shadiqul Hoque  1 , Mathew Kottarathara  1 , Richa Parikh  1 , Amani Erra  1 , Angel A Mitma  1 , Pankaj Mathur  1 , Yetunde Ogunsesan  1 , Lakshmi Yarlagadda  1 , Sravani Gundarlapalli  1 , Sharmilan Thanendrarajan  1 , Maurizio Zangari  1 , Frits Van Rhee  1 , Guido Tricot  1 , Carolina Schinke  5
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Predicting risk of progression in relapsed multiple myeloma using traditional risk models, focal lesion assessment with PET-CT and minimal residual disease status

David Baker et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Reassessment of traditional risk factors in first multiple myeloma relapse shows improved prognostic accuracy compared to their evaluation at diagnosis (shown in the Online Supplementary Appendix). GEP70 high-risk (HR) patients at relapse had significant worse progression-free survival (PFS) (A), and OS (B) compared to low-risk (LR) patients, P<0.01. HR fluorescence in situ hybridization (FISH) included translocation t14;16, t4;14 and del 17p and showed worse PFS (P=0.1) (C) and OS (P<0.05) (D), compared to patients with LR FISH. Assessment of revised International Staging System (RISS) at relapse showed significant worse PFS, E, and OS, F, for patients with RISS 2+3 compared to patients with RISS stage I. The presence of >3 focal lesions by positron emission tomography and computed tomography (PET CT) at relapse was associated with worse PFS (H) and OS (I) in first relapse. The results were not significant, likely due to the relative small patient number. Achievement of minimal residual disease (MRD) negativity after first relapse was a powerful marker for significantly improved PFS (J) and OS (K).
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