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. 2021 Dec 1;106(12):3249-3252.
doi: 10.3324/haematol.2021.279509.

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels

Jonathan Douxfils  1 , Caroline Vayne  2 , Claire Pouplard  2 , Thomas Lecompte  3 , Julien Favresse  4 , Florence Potier  5 , Emy Gasser  6 , Valérie Mathieux  7 , Jean-Michel Dogné  8 , Yves Gruel  2 , Jérôme Rollin  2 , François Mullier  9
Affiliations

Fatal exacerbation of ChadOx1-nCoV-19-induced thrombotic thrombocytopenia syndrome after initial successful therapy with intravenous immunoglobulins - a rational for monitoring immunoglobulin G levels

Jonathan Douxfils et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Clinical and laboratory data of the case. CRP: C-reactive protein; CODP: chronic obstructive pulmonary disease; HIT: heparin-induced thrombocytopenia; od: once daily.
Figure 2.
Figure 2.
Dilution experiments on samples collected at day 1 post-admission (diagnosis), days 4 post-admission (after IVIg administration), day 7 post-admission (marked clinical improvement with platelet count normalization) and day 15 post-admission (deterioration of patient’s status and death). Dilutions were made in normal heated plasma (containing normal immunoglobulin G [IgG] level) or in modified Tyrode’s buffer at 1/10, 1/20, 1/40 dilution ratios. Platelet activation was assessed without heparin in platelet-activating anti-platelet factor 4-serotonin-release assay (PF4-SRA) and results are expressed in percentage of serotonin release. IVIG: intravenous immunoglobulin.
See this image and copyright information in PMC

References

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