Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Steven G Deeks¹, Nancie Archin², Paula Cannon³, Simon Collins⁴, R Brad Jones⁵, Marein A W P de Jong⁶, Olivier Lambotte⁷, Rosanne Lamplough⁸, Thumbi Ndung'u^{9

10

11}, Jeremy Sugarman¹², Caroline T Tiemessen¹³, Linos Vandekerckhove¹⁴, Sharon R Lewin^{15

16

17}; International AIDS Society (IAS) Global Scientific Strategy working group

Collaborators, Affiliations

Collaborators

International AIDS Society (IAS) Global Scientific Strategy working group:
Steven Deeks, Sharon Lewin, Marein de Jong, Zaza Ndhlovu, Nicolas Chomont, Zabrina Brumme, Kai Deng, Luke Jasenosky, Richard Jefferys, Aurelio Orta-Resendiz, Frank Mardarelli, Monique Nijhuis, Katharine Bar, Bonnie Howell, Alex Schneider, Gabriela Turk, Rose Nabatanzi, Joel Blankson, J Victor Garcia, Mirko Paiardini, Jan van Lunzen, Christina Antoniadi, Fernanda Heloise Côrtes, Susana Valente, Ole S Søgaard, Ricardo Sobhie Diaz, Melannie Ott, Richard Rick Dunham, Siegfried Schwarze, Santiago Perez Patrigeon, Josephine Nabukenya, Marina Caskey, Beatriz Mothe, Fu Sheng Wang, Sarah Fidler, Devi SenGupta, Stephan Dressler, Mitch Matoga, Hans-Peter Kiem, Pablo Tebas, Cissy Kityo, Boro Dropulic, Michael Louella, Kumitaa Theva Das, Deborah Persaud, Ann Chahroudi, Katherine Luzuriaga, Thanyawee Puthanakit, Jeffrey Safrit, Gaerolwe Masheto, Karine Dubé, Jennifer Power, Jessica Salzwedel, Udom Likhitwonnawut, Jeff Taylor, Oguzhan Latif Nuh, Krista Dong, Edward Nelson Kankaka

Affiliations

¹ University of California San Francisco, San Fransisco, CA, USA. Steve.deeks@ucsf.edu.
² UNC HIV Cure Center, Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
³ University of Southern California, Los Angeles, CA, USA.
⁴ HIV i-Base, London, UK.
⁵ Weill Cornell Medicine, Cornell University, New York, NY, USA.
⁶ Aidsfonds, Amsterdam, the Netherlands.
⁷ University Paris Saclay, AP-HP, Bicêtre Hospital, UMR1184 INSERM CEA, Le Kremlin Bicêtre, Paris, France.
⁸ International AIDS Society, Geneva, Switzerland.
⁹ Africa Health Research Institute and University of KwaZulu-Natal, Durban, South Africa.
¹⁰ University College London, London, UK.
¹¹ Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
¹² Berman Institute of Bioethics and Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
¹³ National Institute for Communicable Diseases and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
¹⁴ UZ Ghent, Ghent, Belgium.
¹⁵ Victorian Infectious Diseases Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.
¹⁶ Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.
¹⁷ Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.

PMID: 34848888
DOI: 10.1038/s41591-021-01590-5

Review

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Steven G Deeks et al. Nat Med. 2021 Dec.

. 2021 Dec;27(12):2085-2098.

doi: 10.1038/s41591-021-01590-5. Epub 2021 Dec 1.

Authors

Collaborators

International AIDS Society (IAS) Global Scientific Strategy working group:
Steven Deeks, Sharon Lewin, Marein de Jong, Zaza Ndhlovu, Nicolas Chomont, Zabrina Brumme, Kai Deng, Luke Jasenosky, Richard Jefferys, Aurelio Orta-Resendiz, Frank Mardarelli, Monique Nijhuis, Katharine Bar, Bonnie Howell, Alex Schneider, Gabriela Turk, Rose Nabatanzi, Joel Blankson, J Victor Garcia, Mirko Paiardini, Jan van Lunzen, Christina Antoniadi, Fernanda Heloise Côrtes, Susana Valente, Ole S Søgaard, Ricardo Sobhie Diaz, Melannie Ott, Richard Rick Dunham, Siegfried Schwarze, Santiago Perez Patrigeon, Josephine Nabukenya, Marina Caskey, Beatriz Mothe, Fu Sheng Wang, Sarah Fidler, Devi SenGupta, Stephan Dressler, Mitch Matoga, Hans-Peter Kiem, Pablo Tebas, Cissy Kityo, Boro Dropulic, Michael Louella, Kumitaa Theva Das, Deborah Persaud, Ann Chahroudi, Katherine Luzuriaga, Thanyawee Puthanakit, Jeffrey Safrit, Gaerolwe Masheto, Karine Dubé, Jennifer Power, Jessica Salzwedel, Udom Likhitwonnawut, Jeff Taylor, Oguzhan Latif Nuh, Krista Dong, Edward Nelson Kankaka

Affiliations

¹ University of California San Francisco, San Fransisco, CA, USA. Steve.deeks@ucsf.edu.
² UNC HIV Cure Center, Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
³ University of Southern California, Los Angeles, CA, USA.
⁴ HIV i-Base, London, UK.
⁵ Weill Cornell Medicine, Cornell University, New York, NY, USA.
⁶ Aidsfonds, Amsterdam, the Netherlands.
⁷ University Paris Saclay, AP-HP, Bicêtre Hospital, UMR1184 INSERM CEA, Le Kremlin Bicêtre, Paris, France.
⁸ International AIDS Society, Geneva, Switzerland.
⁹ Africa Health Research Institute and University of KwaZulu-Natal, Durban, South Africa.
¹⁰ University College London, London, UK.
¹¹ Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, USA.
¹² Berman Institute of Bioethics and Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
¹³ National Institute for Communicable Diseases and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
¹⁴ UZ Ghent, Ghent, Belgium.
¹⁵ Victorian Infectious Diseases Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.
¹⁶ Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.
¹⁷ Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Sharon.lewin@unimelb.edu.au.

PMID: 34848888
DOI: 10.1038/s41591-021-01590-5

Abstract

Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.

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References

1. Hutter, G. et al. Long-term control of HIV by CCR5 ∆32/∆32 stem-cell transplantation. N. Engl. J. Med. 360, 692–698 (2009). - PubMed - DOI
1. Gupta, R. K. et al. HIV-1 remission following CCR5∆32/∆32 haematopoietic stem-cell transplantation. Nature 568, 244–248 (2019). - PubMed - PMC - DOI
1. Jiang, C. et al. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature 585, 261–267 (2020).
1. Saez-Cirion, A. et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 9, e1003211 (2013). - PubMed - PMC - DOI
1. Lewin, S. R. et al. Multi-stakeholder consensus on a target product profile for an HIV cure. Lancet HIV 8, e42–e50 (2021). - PubMed - DOI

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Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Collaborators

Affiliations

Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical