Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Feb;45(2):144-8.
doi: 10.1136/ard.45.2.144.

HLA-B27 associated cross-reactive marker on the cells of New Zealand patients with ankylosing spondylitis

L E McGuigan, A F Geczy, J K Prendergast, J P Edmonds, H H Hart, H V Bashir

HLA-B27 associated cross-reactive marker on the cells of New Zealand patients with ankylosing spondylitis

L E McGuigan et al. Ann Rheum Dis. 1986 Feb.

Abstract

We have previously shown that antibodies raised in rabbits to certain enteric bacteria will specifically lyse, in a 51Cr release assay, the peripheral blood lymphocytes (PBL) of 80% of HLA-B27 positive patients with ankylosing spondylitis (B27+ AS+) but not the PBL of HLA-B27 positive normal controls (B27+ AS-). Other laboratories have been unable to reproduce these findings. This study was designed to ascertain whether this lack of reproducibility was due to a peculiarity of our B27+ AS+ patients or to technical difficulties in the complement mediated 51Cr release assay. We have shown in this blind study that the PBL of 16 out of 18 B27+ AS+ patients from a New Zealand population were lysed by our antisera but none of the PBL of 20 B27+ AS- normal controls were lysed. The phenomenon of 'cross reactivity' between certain enteric bacteria and B27+ AS+ PBL is not confined to the Sydney AS population.

PubMed Disclaimer

References

    1. Ann Rheum Dis. 1971 Jul;30(4):381-6 - PubMed
    1. Nature. 1980 Feb 21;283(5749):782-4 - PubMed
    1. Nature. 1979 Jan 4;277(5691):68-70 - PubMed
    1. J Rheumatol. 1983 Feb;10(1):102-5 - PubMed
    1. Lancet. 1985 Feb 9;1(8424):344-5 - PubMed

Publication types