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. 2022 Jan 7;50(D1):D480-D487.
doi: 10.1093/nar/gkab1082.

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia  1   2 , Bálint Mészáros  3 , Edoardo Salladini  2 , András Hatos  2 , Rita Pancsa  4 , Lucía B Chemes  5 , Mátyás Pajkos  6 , Tamas Lazar  7   8 , Samuel Peña-Díaz  9   10 , Jaime Santos  9   10 , Veronika Ács  4 , Nazanin Farahi  7   8 , Erzsébet Fichó  4   11 , Maria Cristina Aspromonte  12   13 , Claudio Bassot  14 , Anastasia Chasapi  15 , Norman E Davey  16 , Radoslav Davidović  17 , Laszlo Dobson  3   4 , Arne Elofsson  14 , Gábor Erdős  6 , Pascale Gaudet  18 , Michelle Giglio  19 , Juliana Glavina  5 , Javier Iserte  20 , Valentín Iglesias  9   10 , Zsófia Kálmán  21 , Matteo Lambrughi  22 , Emanuela Leonardi  12   13 , Sonia Longhi  23 , Sandra Macedo-Ribeiro  24   25 , Emiliano Maiani  22 , Julia Marchetti  26 , Cristina Marino-Buslje  20 , Attila Mészáros  7   8 , Alexander Miguel Monzon  2 , Giovanni Minervini  2 , Suvarna Nadendla  19 , Juliet F Nilsson  23 , Marian Novotný  27 , Christos A Ouzounis  15   28 , Nicolás Palopoli  26 , Elena Papaleo  22   29 , Pedro José Barbosa Pereira  24   25 , Gabriele Pozzati  14 , Vasilis J Promponas  30 , Jordi Pujols  9   10 , Alma Carolina Sanchez Rocha  31 , Martin Salas  26 , Luciana Rodriguez Sawicki  26 , Eva Schad  4 , Aditi Shenoy  14 , Tamás Szaniszló  6 , Konstantinos D Tsirigos  32 , Nevena Veljkovic  17 , Gustavo Parisi  26 , Salvador Ventura  9   10   33 , Zsuzsanna Dosztányi  6 , Peter Tompa  4   7   8 , Silvio C E Tosatto  2 , Damiano Piovesan  2
Affiliations

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia et al. Nucleic Acids Res. .

Abstract

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

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Figures

Figure 1.
Figure 1.
Number of experimental evidence of disorder used in DisProt by year of publication. Different colors correspond to different experimental techniques as reported in the corresponding publications. Publications older than 1990 are grouped in the first bar.
Figure 2.
Figure 2.
Region length distribution of pieces of evidence inferred using various experimental techniques in DisProt. Data in the main plot starts at length 40, the full distribution is shown in the inset plot.
Figure 3.
Figure 3.
Amino acid composition of DisProt regions. Amino acids are sorted by the Kyte-Doolittle hydrophobicity scale. The amino acid frequency is calculated considering only disordered residues. The enrichment is calculated and normalized over the TrEMBL database frequencies (release 2021_03). Color intensity is proportional to bar height.
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