Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:434:123-134.
doi: 10.1007/978-3-030-86016-5_6.

Immune Niche Within the Peritoneal Cavity

Yasutaka Okabe  1
Affiliations
Review

Immune Niche Within the Peritoneal Cavity

Yasutaka Okabe. Curr Top Microbiol Immunol. 2021.

Abstract

There are numbers of leukocytes present in peritoneal cavity, not only protecting body cavity from infection but also contributing to peripheral immunity including natural antibody production in circulation. The peritoneal leukocytes compose unique immune compartment, the functions of which cannot be replaced by other lymphoid organs. Atypical lymphoid clusters, called "milky spots", that are located in visceral adipose tissue omentum have the privilege of immune niche in terms of differentiation, recruitment, and activation of peritoneal immunity, yet mechanisms underlying the regulation are underexplored. In this review, I discuss the emerging views of peritoneal immune system in the contexts of its development, organization, and functions.

Keywords: B-1 cell; CXCL13; FALC; Macrophage; Milky spot; Omentum; Peritoneal cavity.

PubMed Disclaimer

References

    1. Abu-Hijleh MF, Habbal OA, Moqattash ST (1995) The role of the diaphragm in lymphatic absorption from the peritoneal cavity. J Anat 186(Pt 3):453–467 - PubMed - PMC
    1. Agalar F, Sayek I, Cakmakci M, Hascelik G, Abbasoglu O (1997) Effect of omentectomy on peritoneal defence mechanisms in rats. Eur J Surg 163:605–609 - PubMed
    1. Aguzzi A, Kranich J, Krautler NJ (2014) Follicular dendritic cells: origin, phenotype, and function in health and disease. Trends Immunol 35:105–113 - PubMed
    1. Ansel KM, Harris RB, Cyster JG (2002) CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16:67–76 - PubMed
    1. Barth MW, Hendrzak JA, Melnicoff MJ, Morahan PS (1995) Review of the macrophage disappearance reaction. J Leukoc Biol 57:361–367 - PubMed

LinkOut - more resources