Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus

Pankaj Gupta¹, Usha Dutta², Pratyaksha Rana³, Manphool Singhal³, Ajay Gulati³, Naveen Kalra³, Raghuraman Soundararajan³, Daneshwari Kalage³, Manika Chhabra³, Vishal Sharma², Vikas Gupta⁴, Thakur Deen Yadav⁴, Lileshwar Kaman⁵, Santosh Irrinki⁵, Harjeet Singh⁴, Yashwant Sakaray⁵, Chandan Krishuna Das⁶, Uma Saikia⁷, Ritambhara Nada⁷, Radhika Srinivasan⁸, Manavjit Singh Sandhu³, Raju Sharma⁹, Nitin Shetty¹⁰, Anu Eapen¹¹, Harmeet Kaur¹², Avinash Kambadakone¹³, Robbert de Haas¹⁴, Vinay K Kapoor¹⁵, Savio George Barreto¹⁶, Atul K Sharma¹⁷, Amol Patel¹⁸, Pramod Garg¹⁹, Sujoy K Pal²⁰, Mahesh Goel²¹, Shraddha Patkar²¹, Anu Behari¹⁵, Anil K Agarwal²², Bhawna Sirohi²³, Milind Javle²⁴, Giuseppe Garcea²⁵, Flavio Nervi²⁶, Volkan Adsay²⁷, Juan Carlos Roa²⁸, Ho-Seong Han²⁹

Affiliations

¹ Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Pankajgupta959@gmail.com.
² Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁵ Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁶ Haematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁷ Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁸ Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁹ Department of Radiology, All India Institute of Medical Education and Research, New Delhi, India.
¹⁰ Department of Interventional Radiology, Tata Memorial Hospital, Mumbai, India.
¹¹ Department of Radiodiagnosis, Christian Medical College, Vellore, India.
¹² Division of Diagnostic Imaging, Department of Abdominal Imaging, MD Anderson Cancer Centre, Houston, TX, USA.
¹³ Abdominal Imaging, Harvard Medical School, Medical Director, Martha's Vineyard Hospital Imaging, Massachusetts General Hospital, Boston, USA.
¹⁴ Radiology, University Medical Center Groningen, Groningen, The Netherlands.
¹⁵ HPB Surgery, Mahatma Gandhi Medical College & Hospital, Jaipur, India.
¹⁶ Division of Surgery and Perioperative Medicine, Flinders Medical Centre, Bedford Park, SA, Australia.
¹⁷ Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
¹⁸ Indian Naval Hospital Ship, Asvini, Mumbai, India.
¹⁹ Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
²⁰ Surgical Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
²¹ Gastrointestinal and HPB Surgery, Tata Memorial Hospital, Mumbai, India.
²² GI Surgery and Liver Transplant, GB Pant Institute of Medical Education and Research and MAM College, New Delhi, India.
²³ Medical Oncology, Apollo Proton Cancer Centre, Chennai, India.
²⁴ Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Centre, Houston, USA.
²⁵ HPB Surgery, University of Leicester, Leicester, UK.
²⁶ Department of Gastroenterology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
²⁷ Department of Pathology, Koc University Hospitals, Istanbul, Turkey.
²⁸ Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile.
²⁹ Department of Surgery, College of Medicine, Seoul National University Bundang Hospital Seoul National University, Seongnam-si, South Korea.

PMID: 34851429
DOI: 10.1007/s00261-021-03360-w

Review

Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus

Pankaj Gupta et al. Abdom Radiol (NY). 2022 Feb.

. 2022 Feb;47(2):554-565.

doi: 10.1007/s00261-021-03360-w. Epub 2021 Dec 1.

Authors

Affiliations

¹ Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Pankajgupta959@gmail.com.
² Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁴ Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁵ Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁶ Haematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁷ Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁸ Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
⁹ Department of Radiology, All India Institute of Medical Education and Research, New Delhi, India.
¹⁰ Department of Interventional Radiology, Tata Memorial Hospital, Mumbai, India.
¹¹ Department of Radiodiagnosis, Christian Medical College, Vellore, India.
¹² Division of Diagnostic Imaging, Department of Abdominal Imaging, MD Anderson Cancer Centre, Houston, TX, USA.
¹³ Abdominal Imaging, Harvard Medical School, Medical Director, Martha's Vineyard Hospital Imaging, Massachusetts General Hospital, Boston, USA.
¹⁴ Radiology, University Medical Center Groningen, Groningen, The Netherlands.
¹⁵ HPB Surgery, Mahatma Gandhi Medical College & Hospital, Jaipur, India.
¹⁶ Division of Surgery and Perioperative Medicine, Flinders Medical Centre, Bedford Park, SA, Australia.
¹⁷ Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
¹⁸ Indian Naval Hospital Ship, Asvini, Mumbai, India.
¹⁹ Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
²⁰ Surgical Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
²¹ Gastrointestinal and HPB Surgery, Tata Memorial Hospital, Mumbai, India.
²² GI Surgery and Liver Transplant, GB Pant Institute of Medical Education and Research and MAM College, New Delhi, India.
²³ Medical Oncology, Apollo Proton Cancer Centre, Chennai, India.
²⁴ Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Centre, Houston, USA.
²⁵ HPB Surgery, University of Leicester, Leicester, UK.
²⁶ Department of Gastroenterology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
²⁷ Department of Pathology, Koc University Hospitals, Istanbul, Turkey.
²⁸ Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile.
²⁹ Department of Surgery, College of Medicine, Seoul National University Bundang Hospital Seoul National University, Seongnam-si, South Korea.

PMID: 34851429
DOI: 10.1007/s00261-021-03360-w

Abstract

The Gallbladder Reporting and Data System (GB-RADS) ultrasound (US) risk stratification is proposed to improve consistency in US interpretations, reporting, and assessment of risk of malignancy in gallbladder wall thickening in non-acute setting. It was developed based on a systematic review of the literature and the consensus of an international multidisciplinary committee comprising expert radiologists, gastroenterologists, gastrointestinal surgeons, surgical oncologists, medical oncologists, and pathologists using modified Delphi method. For risk stratification, the GB-RADS system recommends six categories (GB-RADS 0-5) of gallbladder wall thickening with gradually increasing risk of malignancy. GB-RADS is based on gallbladder wall features on US including symmetry and extent (focal vs. circumferential) of involvement, layered appearance, intramural features (including intramural cysts and echogenic foci), and interface with the liver. GB-RADS represents the first collaborative effort at risk stratifying the gallbladder wall thickening. This concept is in line with the other US-based risk stratification systems which have been shown to increase the accuracy of detection of malignant lesions and improve management.

Keywords: Gallbladder cancer; Method; Scoring; Ultrasound.

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GB-RADS score, a possible role for CEUS?
Boccatonda A, Cocco G, D'Ardes D, Schiavone C. Boccatonda A, et al. Abdom Radiol (NY). 2023 Mar;48(3):1199-1201. doi: 10.1007/s00261-023-03806-3. Epub 2023 Jan 21. Abdom Radiol (NY). 2023. PMID: 36680598 No abstract available.

References

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1. Gupta P, Kumar M, Sharma V, Dutta U, Sandhu MS (2020) Evaluation of gallbladder wall thickening: a multimodality imaging approach. Expert Rev Gastroenterol Hepatol 14:463-473 - DOI

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Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus

Affiliations

Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus

Authors

Affiliations

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Full Text Sources

Medical