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Review
. 2021 Dec 1;23(12):80.
doi: 10.1007/s11883-021-00977-6.

Statins and Inflammation

Martin Satny  1 , Jaroslav A Hubacek  2 , Michal Vrablik  3   4
Affiliations
Review

Statins and Inflammation

Martin Satny et al. Curr Atheroscler Rep. .

Abstract

Purpose of review: Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms' initiation and progression of atherosclerosis. Statins belong to most successful therapeutic agents in the prevention and treatment of atherothrombotic vascular disease. Their non-lipid related effects including suppression of inflammation have been repeatedly proven in both experimental and clinical settings.

Recent findings: Recently, the importance of inflammation in the process of atherosclerosis has been confirmed by interventions targeting inflammation selectively. Clinical trial with selective inhibitor of a principal inflammatory mediator interleukin 1-beta - canakinumab - confirmed the notion of direct vasculoprotective effects of primarily targeting inflammation. This has increased interest in the non-lipid, pleiotropic and, particularly, anti-inflammatory effects of statins. Anti-inflammatory effects of statins have been proven both experimentally and in clinical settings beyond any doubt. They comprise a direct positive effect on not only many cell types and pathways that are lipid independent but, also, some that are mediated by lipid modification. Undoubtedly, suppression of inflammatory response by statins contributes to their generally positive action in atherosclerosis and represents an important part of the vasculo- and atheroprotective effect of this drug class.

Keywords: Atherosclerosis; Biomarkers; Cardiovascular; Endothelial function; Inflammation; Pleiotropy; Statins.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study, 2004. 364(9438), 937–952. https://doi.org/10.1016/S0140-6736(04)17018-9 .
    1. Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. European Heart Journal, 2020. 41(1) 111–188.
    1. •• Montecucco F, Liberale L, Bonaventura A, et al. The role of inflammation in cardiovascular outcome. Curr Atheroscler. 2017. Rep. 9(3)11. A comprehensive review focusing on and summarizing the roles of innate immunity in the vascular inflammation initiation and propagation and its role in cardiovascular events risk.
    1. Chatzizisis Y, CoskunA, Jonas M, et al. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379–93.
    1. •• Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1696. A landmark paper summarizing the inflammatory aspects of atherosclerosis and involvement of different cellular and chemical species in different stages of atherogenesis.

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