Comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics"

Hilma Hólm¹, Patrick Sulem¹, Vinicius Tragante¹, Unnur Thorsteinsdottir^{1

2}, Daniel F Gudbjartsson^{1

3}, Kari Stefansson^{1

2}

Affiliations

¹ deCODE genetics, Amgen Inc., 102 Reykjavik, Iceland.
² Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
³ School of Engineering and Natural Sciences, University of Iceland, 101 Reykjavik, Iceland.

PMID: 34851692
DOI: 10.1126/scitranslmed.abe8497

Comment

Comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics"

Hilma Hólm et al. Sci Transl Med. 2021 Dec.

. 2021 Dec;13(622):eabe8497.

doi: 10.1126/scitranslmed.abe8497. Epub 2021 Dec 1.

Authors

Hilma Hólm¹, Patrick Sulem¹, Vinicius Tragante¹, Unnur Thorsteinsdottir^{1

2}, Daniel F Gudbjartsson^{1

3}, Kari Stefansson^{1

2}

Affiliations

¹ deCODE genetics, Amgen Inc., 102 Reykjavik, Iceland.
² Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
³ School of Engineering and Natural Sciences, University of Iceland, 101 Reykjavik, Iceland.

PMID: 34851692
DOI: 10.1126/scitranslmed.abe8497

Abstract

Genetic data do not provide evidence for SOST inhibition causing cardiovascular disease.

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Comment in

Response to comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics".
Bovijn J, Krebs K, Chen CY, Boxall R, Censin JC, Ferreira T, Pulit SL, Glastonbury CA, Laber S, Millwood IY, Lin K, Li L, Chen Z, Milani L, Smith GD, Walters RG, Mägi R, Neale BM, Lindgren CM, Holmes MV. Bovijn J, et al. Sci Transl Med. 2021 Dec;13(622):eabf4530. doi: 10.1126/scitranslmed.abf4530. Epub 2021 Dec 1. Sci Transl Med. 2021. PMID: 34851696

Comment on

Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics.
Bovijn J, Krebs K, Chen CY, Boxall R, Censin JC, Ferreira T, Pulit SL, Glastonbury CA, Laber S, Millwood IY, Lin K, Li L, Chen Z, Milani L, Smith GD, Walters RG, Mägi R, Neale BM, Lindgren CM, Holmes MV. Bovijn J, et al. Sci Transl Med. 2020 Jun 24;12(549):eaay6570. doi: 10.1126/scitranslmed.aay6570. Sci Transl Med. 2020. PMID: 32581134 Free PMC article.

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Comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics"

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Comment on "Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics"

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