Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Jan 1;68(1):73-78.
doi: 10.1097/MAT.0000000000001398.

Agreement Between the TEG 6s and TEG 5000 Analyzers in Extracorporeal Membrane Oxygenation

Abhimanyu Chandel  1 , Mehul Desai  2 , Christopher S King  3 , Saloni Patolia  4 , Anika I Raja  5 , Ramesh Singh  6 , Heidi J Dalton  7
Affiliations
Observational Study

Agreement Between the TEG 6s and TEG 5000 Analyzers in Extracorporeal Membrane Oxygenation

Abhimanyu Chandel et al. ASAIO J. .

Abstract

Thromboelastography (TEG) evaluates viscoelastic properties of blood clot formation. The TEG 5000 analyzer is commonly used but prone to errors related to vibration or operator error. The TEG 6s was developed to overcome these limitations. Performance of TEG 6s compared with TEG 5000 has not been reported in extracorporeal membrane oxygenation (ECMO). We compared the agreement between devices via a single-center prospective observational study in hospitalized adult patients on ECMO. Data for both devices were collected daily for 3 days after ECMO initiation. Standard tests for method comparison were used. Thirty-four matching samples were available for analysis. Minimal bias was noted; however, the limit of agreement was wide for TEG parameters. Visually, agreement was better for values within the reference ranges of the tests. Lin's coefficients demonstrated moderate correlation for reaction time and alpha angle (0.58; 95% confidence interval [CI], 0.31-0.76 and 0.63; 95% CI, 0.40-0.78, respectively). Excellent correlation was demonstrated for kinetic time and maximum amplitude (0.88; 95% CI, 0.79-0.94 and 0.89; 95% CI, 0.79-0.94). The TEG 6s device may represent an acceptable surrogate for the TEG 5000 in patients on ECMO. However, limitations in reliability were noted, and the devices may not be interchangeable when results fall outside of the reference values.

PubMed Disclaimer

Conflict of interest statement

Disclosure: H.J.D. serves as a consultant to Innovative ECMO Concepts Inc. The other authors have no conflicts of interest to report.

References

    1. Lequier L, Annich G, Al-Ibrahim O, et al.: ELSO Anticoagulation Guideline. 2014. Available at: https://www.elso.org/Resources/Guidelines.aspx . Accessed August 11, 2020.
    1. Bolliger D, Seeberger MD, Tanaka KA: Principles and practice of thromboelastography in clinical coagulation management and transfusion practice. Transfus Med Rev. 26: 1–13, 2012.
    1. Ak K, Isbir CS, Tetik S, et al.: Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: A prospective randomized study. J Card Surg. 24: 404–410, 2009.
    1. Brearton C, Rushton A, Parker J, et al.: Performance evaluation of a new point of care viscoelastic coagulation monitoring system in major abdominal, orthopaedic and vascular surgery. Platelets. 31: 1052–1059, 2020.
    1. Deppe AC, Weber C, Zimmermann J, et al.: Point-of-care thromboelastography/thromboelastometry-based coagulation management in cardiac surgery: A meta-analysis of 8332 patients. J Surg Res. 203: 424–433, 2016.

Publication types