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Review
. 2022;22(12):2204-2240.
doi: 10.2174/1871520621666211201152815.

Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Cauê Benito Scarim  1   2 , Chung Man Chin  1   2   3
Affiliations
Review

Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds

Cauê Benito Scarim et al. Anticancer Agents Med Chem. 2022.

Abstract

Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving these three pharmacophore classes (thiazoles, triazoles, and thiosemicarbazones) in medicinal chemistry over the last decade (2011-2021) with a focus on MCF-7 adenocarcinoma breast cancer cells. Our objective is to facilitate drug discovery of novel chemotherapeutic agents by detailing anti-proliferative compounds.

Keywords: MCF-7; Thiazoles; anti-proliferative; breast cancer; thiosemicarbazones; triazoles.

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