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. 2022 May 24;75(3):325-327.
doi: 10.7883/yoken.JJID.2021.745. Epub 2021 Nov 30.

Influenza A Virus Infection in Domestic Ferrets

Yudai Kuroda  1   2 , Ai Okada  1 , Hiroshi Shimoda  1 , Yasutsugu Miwa  3 , Akiko Watamori  3 , Hiroho Ishida  4 , Shin Murakami  4 , Ayato Takada  5 , Taisuke Horimoto  4 , Ken Maeda  1   2
Affiliations

Influenza A Virus Infection in Domestic Ferrets

Yudai Kuroda et al. Jpn J Infect Dis. .

Abstract

Ferrets are animals that are known to be susceptible to influenza A virus (IAV) infection. To evaluate the risk of IAV transmission from diseased ferrets to humans, a survey was performed to detect specific antibodies against the H1, H3, H5, and H7 subtypes of IAV. Using enzyme-linked immunosorbent assay for hemagglutinin proteins, we found a high positive rate for the H1 (24.1%) and H3 (5.2%) subtypes. The results were confirmed by a virus neutralization test for representative antibody-positive serum samples. We also detected hemagglutinin and neuraminidase genes in two ferrets showing acute respiratory disease and whose owner was diagnosed with IAV infection; a human H1N1pdm virus was isolated from one of these ferrets. Our findings suggest that attention should be paid to IAV infection from humans to ferrets and vice versa.

Keywords: ferret; influenza; reverse zoonosis; seroprevalence.

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