Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients

Abstract

The prevalence of diabetes mellitus continues to increase from year to year. Critical limb ischemia (CLI) is one of the complications of diabetes mellitus with a high mortality rate and requires amputation if not treated properly. Mean platelet volume (MPV) is an indicator of platelet activation and is expected to be a predictor of CLI in diabetes mellitus patients. This article investigates the relationship between MPV and the incidence of CLI in diabetes mellitus patients. This case-control study was conducted using the vascular registry of Dr. Sardjito Hospital, Yogyakarta, Indonesia, from January 2016 to December 2016. The relationship between MPV and the incidence of CLI was analyzed using bivariate and multivariate analysis. There was a significant association between MPV and incidence of CLI in diabetes mellitus patient both on bivariate analysis ( p = 0.035) and multivariate analysis ( p = 0.029). Diabetes mellitus patients with MPV values of ≥ 9.8 fl had a protective effect to prevent the incidence of CLI (bivariate analysis: odds ratio [OR] = 0.366, 95% confidence interval [CI] = 0.142-0.943; multivariate analysis: adjusted OR = 0.288, 95% CI = 0.09-0.88). Confounding factors such as sex, age, obesity, and use of antiplatelet agents were not associated with the incidence of CLI ( p > 0.05). Meanwhile, history of dyslipidemia as a confounding factor was significantly associated with the incidence of CLI ( p < 0.05). Low MPV was found to be significantly associated with the incidence of CLI in diabetes mellitus patients.

Keywords: case–control; critical limb ischemia; diabetes mellitus; mean platelet volume.