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Review
. 2021 Nov 22:2021:6606830.
doi: 10.1155/2021/6606830. eCollection 2021.

Association of KCNQ1rs2237892C⟶T Gene with Type 2 Diabetes Mellitus: A Meta-Analysis

Wen-Jia Han  1 , Jian-Yi Deng  2 , Hua Jin  3 , Li-Ping Yin  4 , Jin-Xia Yang  5 , Jiang-Jie Sun  5
Affiliations
Review

Association of KCNQ1rs2237892C⟶T Gene with Type 2 Diabetes Mellitus: A Meta-Analysis

Wen-Jia Han et al. J Diabetes Res. .

Abstract

Background: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases in adults, causing high morbidity and mortality worldwide. In recent years, the prevalence of T2DM has been increasing significantly, and genome-wide association studies (GWAS) have shown that KCNQ1 significantly increases the risk of T2DM.

Objective: To find large-scale evidence on whether the KCNQ1rs2237892C⟶T gene polymorphism is associated with T2DM susceptibility.

Methods: A comprehensive review of the Chinese and English literature on the association of T2DM with KCNQ1rs2237892 is published by PubMed and Baidu Academic. The included literature was part or all of the studied loci which were evaluated for association with T2DM. Forest plots were made of the included literature to analyze the association of KCNQ1 with polymorphisms of the studied loci, and funnel plots and Egger's test were used to evaluate the publication bias of the selected included literature.

Results: Ten case-control studies including a total of 7027 cases and 8208 controls met our inclusion criteria. Allele (C allele frequency distribution) (OR: 1.19; 95% CI: 0.87,1.62; P < 0.00001), recessive (OR: 0.73; 95% CI: 0.45,1.18; P < 0.00001) genetic model under the full population was observed between KCNQ1rs2237892C⟶T gene polymorphism and T2DM without a significant relationship. In a stratified analysis by race, a meaningful association was found in non-Asian populations under the allelic genetic model, but no association was found in Asian populations.

Conclusion: This meta-analysis showed no significant association between the rs2237892 polymorphism of the KCNQ1 gene and the risk of T2DM.

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Conflict of interest statement

The authors state that the study was conducted without any commercial or financial relationship.

Figures

Figure 1
Figure 1
Literature screening process.
Figure 2
Figure 2
Forest plot of meta-analysis of the association between KCNQ12237892 locus and T2DM under the allele model.
Figure 3
Figure 3
Forest plot of meta-analysis of the association between KCNQ12237892 locus and T2DM under the allele model (stratified analysis).
Figure 4
Figure 4
Forest plot of meta-analysis of the association between KCNQ12237892 locus and T2DM under the recessive model.
Figure 5
Figure 5
Forest plot of meta-analysis of the association between KCNQ12237892 locus and T2DM under the recessive model (stratified analysis).
See this image and copyright information in PMC

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