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. 2022:2402:13-20.
doi: 10.1007/978-1-0716-1843-1_2.

Preparing Ion Channel Switch Membrane-Based Biosensors

Amani Alghalayini  1   2 , Charles G Cranfield  3   4 , Bruce A Cornell  4   5 , Stella M Valenzuela  3   4   6
Affiliations

Preparing Ion Channel Switch Membrane-Based Biosensors

Amani Alghalayini et al. Methods Mol Biol. 2022.

Abstract

Monitoring the changes in membrane conductance using electrical impedance spectroscopy is the platform of membrane-based biosensors in order to detect a specific target molecule. These biosensors represent the amalgamation of an electrical conductor such as gold and a chemically tethered bilayer lipid membrane with specific incorporated ion channels such as gramicidin-A that is further functionalized with detector molecules of interest.

Keywords: Biosensor; Electrical impedance spectroscopy; Gramicidin-A; Ion channels; Tethered bilayer lipid membranes.

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References

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