Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan;290(1):66-72.
doi: 10.1111/febs.16308. Epub 2021 Dec 22.

Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning

Natalia Y Martynova  1 , Elena A Parshina  1 , Andrey G Zaraisky  1
Affiliations
Free article
Review

Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning

Natalia Y Martynova et al. FEBS J. 2023 Jan.
Free article

Abstract

The Lim-domain protein Zyxin was initially identified as a minor actin cytoskeleton protein that regulates the assembly and repair of actin filaments. At the same time, additional functions revealed for Zyxin in recent decades indicate that this protein can also play an important role in regulating gene expression and cell differentiation. In this review, we analysed the data in the literature pointing to Zyxin as one of the possible molecular hubs linking morphogenetic cell movements with gene expression, stem cell status regulation and pattern formation during the most complex processes in organism life, embryogenesis.

Keywords: development; differentiation; morphogenesis; pluripotency; protein interactions; transcription factor; zyxin.

PubMed Disclaimer

References

    1. Smith MA, Hoffman LM & Beckerle MC (2014) LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol 24, 575-583.
    1. Hervy M, Hoffman L & Beckerle MC (2006) From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol 18, 524-532.
    1. Wang YX, Wang DY, Guo YC & Guo J (2019) Zyxin: a mechanotransductor to regulate gene expression. Eur Rev Med Pharmacol Sci 23, 413-425.
    1. Sabino F, Madzharova E & Auf dem Keller U (2020) Cell density-dependent proteolysis by HtrA1 induces translocation of Zyxin to the nucleus and increased cell survival. Cell Death Dis 11, 674.
    1. Wang Y & Gilmore TD (2003) Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear. Biochim Biophys Acta 1593, 115-120.

Publication types

LinkOut - more resources