Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2021 Dec 2;43(2):211-218.
doi: 10.1515/hmbci-2021-0015.

Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial

Maryam Mohajeranirad  1 , Naser Saeidi  2 , Mohammad Kamali Nejad  3 , Amir Almasi-Hashiani  4 , Mehdi Salehi  1 , Seyed Amirhossein Latifi  1
Affiliations
Randomized Controlled Trial

Effects of Helichrysum Psudoplicatum supplementation on pruritus intensity, fatigue, quality of life and anorexia in hemodialysis patients: a randomized, double-blind placebo-controlled trial

Maryam Mohajeranirad et al. Horm Mol Biol Clin Investig. .

Abstract

Objectives: Anorexia, fatigue and pruritus are common complications of hemodialysis (HD) patients. Today, the use of medicinal plants is more than synthetic drugs due to their safety. Therefore, we designed a randomized controlled clinical trial to evaluate the effects of Helichrysum psudoplicatum (H. psudoplicatum) supplementation on biochemical parameters, pruritus intensity, fatigue, quality of life and anorexia in HD patients.

Methods: This randomized, double-blind, placebo-controlled trial was performed on 50 subjects with, aged 55-65 years old. HD patients were randomly divided into two groups. Intervention group received 250 mg/day of H. psudoplicatum supplement capsule for 6 weeks (n=25), and the placebo group was given placebo capsule for the same time duration and dosage (n=25). The serum concentrations of urea, creatinine, albumin and hemoglobin were measured enzymatically methods. Anorexia, pruritus intensity, quality of life the dialysis patients with pruritus and fatigue score was measured using a Simplified Nutritional Appetite Questionnaire (SNAQ), Numerical rating scale (NRS), Fatigue severity scale (FSS) and ItchyQoL questionnaire, respectively. Shapiro-Wilk and independent-samples t-test or Mann-Whitney test were used for the analysis of the data.

Results: The results showed that the H. psudoplicatum supplementation significantly improved the pruritus intensity, quality of life the dialysis patients with pruritus and fatigue in HD patients, for 6 weeks (p<0.001). However, it did not significantly effect on the anorexia, albumin, hemoglobin, urea, creatinine, arm circumference, and body mass index (p>0.05).

Conclusions: According to the results of this study, H. psudoplicatum supplementation can be effective as an adjunct therapy to improve pruritus intensity, quality of life, fatigue and relative improvement of anorexia in HD patients.

Keywords: Helichrysum psudoplicatum; biochemical parameters; fatigue; pruritus intensity; quality of life; supp-lementation.

PubMed Disclaimer

References

    1. Senanayake, S, Gunawardena, N, Palihawadana, P, Bandara, P, Haniffa, R, Karunarathna, R, et al.. Symptom burden in chronic kidney disease; a population based cross sectional study. BMC Nephrol 2017;18:228. https://doi.org/10.1186/s12882-017-0638-y.
    1. Anderson, S, Halter, JB, Hazzard, WR, Himmelfarb, J, Horne, FM, Kaysen, GA, et al.. Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol JASN 2009;20:1199–209. https://doi.org/10.1681/asn.2008080860.
    1. Ojo, A. Addressing the global burden of chronic kidney disease through clinical and translational research. Trans Am Clin Climatol Assoc 2014;125:229–43. discussion 43–6.
    1. Abraham, S, Ramachandran, A. Estimation of quality of life in haemodialysis patients. Indian J Pharmaceut Sci 2012;74:583–7. https://doi.org/10.4103/0250-474x.110624.
    1. Msaad, R, Essadik, R, Mohtadi, K, Meftah, H, Lebrazi, H, Taki, H, et al.. Predictors of mortality in hemodialysis patients. Pan Afr Med J 2019;33:61–74. https://doi.org/10.11604/pamj.2019.33.61.18083.

Publication types

LinkOut - more resources