doi: 10.1016/0014-5793(86)81179-6.
Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T-lymphocytes
- PMID: 3485539
- DOI: 10.1016/0014-5793(86)81179-6
Item in Clipboard
Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T-lymphocytes
FEBS Lett.
.
Free article
Abstract
When quiescent murine T-lymphocyte cells were stimulated by the addition of interleukin 2 (IL-2), they reinitiated DNA synthesis after a lag period of 5 h. Under these conditions, rapid but transient phosphorylation of two cellular proteins with Mr values of 27 000 and 26 000 was detected; maximal phosphorylation occurred within 10-15 min after the addition of IL-2. The protein of Mr 27 000 contained phosphoserine, while the protein of Mr 26 000 contained phosphothreonine.
Similar articles
-
Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells.Biochem J. 1987 Feb 15;242(1):211-9. doi: 10.1042/bj2420211. Biochem J. 1987. PMID: 3496080 Free PMC article.
-
Murine T-lymphocyte proliferation induced by interleukin 2 correlates with a transient increase in p56lck kinase activity and the tyrosine phosphorylation of a 97-kDa protein.Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3187-91. doi: 10.1073/pnas.90.8.3187. Proc Natl Acad Sci U S A. 1993. PMID: 7682694 Free PMC article.
-
Stimulated rat T cell-derived inhibitory factor for cellular DNA synthesis (STIF). III. Effect on cell proliferation and immune responses.J Immunol. 1985 May;134(5):3172-8. J Immunol. 1985. PMID: 2580017
-
Interleukin 2-dependent phosphorylation of interleukin 2 receptors and other T cell membrane proteins.J Immunol. 1986 Apr 1;136(7):2470-7. J Immunol. 1986. PMID: 3005413
-
Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells.Biochim Biophys Acta. 1990 May 2;1052(2):313-22. doi: 10.1016/0167-4889(90)90227-5. Biochim Biophys Acta. 1990. PMID: 2334739
Cited by
-
Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts.Biochem J. 1986 Sep 1;238(2):451-7. doi: 10.1042/bj2380451. Biochem J. 1986. PMID: 3800947 Free PMC article.
-
Interleukin-2 versus phorbol-ester-induced cellular events in normal T-lymphocytes.Med Oncol Tumor Pharmacother. 1986;3(3-4):237-46. doi: 10.1007/BF02935000. Med Oncol Tumor Pharmacother. 1986. PMID: 3100884
-
Interleukin 2 and a lactogen regulate proliferation and protein phosphorylation in Nb2 cells.Biochem J. 1988 Jan 15;249(2):333-8. doi: 10.1042/bj2490333. Biochem J. 1988. PMID: 3124825 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
