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Editorial
. 2021 Dec 3;129(12):1102-1104.
doi: 10.1161/CIRCRESAHA.121.320328. Epub 2021 Dec 2.

Resident Macrophages in the Heart: Cardioprotective Under Pressure

Mohamed Ameen Ismahil  1 , Sumanth D Prabhu  1
Affiliations
Editorial

Resident Macrophages in the Heart: Cardioprotective Under Pressure

Mohamed Ameen Ismahil et al. Circ Res. .
No abstract available

Keywords: Editorials; fibrosis; heart failure; macrophages; monocytes; ventricular remodeling.

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Figures

Figure
Figure. Resident macrophages (M∅s) in the pressure-overloaded heart.
Early (1 week) after the imposition of pressure overload via transverse aortic constriction (TAC) in the mouse heart, there is significant expansion of both CCR2− resident M∅s (multiple subpopulations) and CCR2+ monocyte-derived M∅s. These two M∅ populations exert differential and opposing effects on cardiac remodeling - resident M∅s induce antifibrotic and pro-angiogenic responses that counteract the tissue injurious and pro-inflammatory responses mediated by monocyte-derived M∅s. Preferential resident M∅ depletion using a CD115 blocking antibody prior to TAC disrupts this balance to promote fibrosis, microvascular rarefaction, late adverse remodeling and heart failure. Schema based on the study by Revelo et al (19)
See this image and copyright information in PMC

Comment on

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