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. 2021 Dec 2;17(12):e1010035.
doi: 10.1371/journal.ppat.1010035. eCollection 2021 Dec.

Glycerol, a possible new player in the biology of trypanosomes

Frédéric Bringaud  1 , Nicolas Plazolles  1 , Erika Pineda  1 , Corinne Asencio  1 , Oriana Villafraz  1 , Yoann Millerioux  1 , Loïc Rivière  1 , Emmanuel Tetaud  1
Affiliations

Glycerol, a possible new player in the biology of trypanosomes

Frédéric Bringaud et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist

Figures

Fig 1
Fig 1. Mechanism of metabolic contest between glycosomal HK and GK.
Pathways leading to excretion of end products (succinate, acetate, and pyruvate, highlighted in white rectangle) from metabolism of glucose and glycerol are indicated in red and blue, respectively. The production and consumption of ATP within the glycosomes are indicated and maintenance of the glycosomal ATP balance is highlighted by black arrows. The thickness of the arrows reflects metabolic fluxes and metabolic steps detected only at relatively very low activity or not at all are represented by dotted lines. The GK/HK activity ratio for procyclic and bloodstream forms is indicated below the corresponding schemes (A–B and C–D, respectively). Enzymes are (those underlined are glycosomal kinases producing or consuming ATP) the following: 1, hexokinase (HK); 2, glucose-6-phosphate isomerase; 3, phosphofructokinase; 4, aldolase; 5, triose-phosphate isomerase; 6, glyceraldehyde-3-phosphate dehydrogenase; 7, phosphoglycerate kinase (PGK); 8, phosphoglycerate mutase; 9, enolase; 10, pyruvate kinase; 11, phosphoenolpyruvate carboxykinase (PEPCK); 12, malate dehydrogenase; 13, fumarase; 14, NADH-dependent fumarate reductase; 15, pyruvate phosphate dikinase (PPDK); 16, pyruvate dehydrogenase complex; 17, acetate:succinate CoA-transferase; 18, acetyl-CoA thioesterase; 19, glycerol kinase (GK); 20, glycerol-3-phosphate dehydrogenase; 21, fructose-1,6-bisphosphatase. Abbreviations are: BSF, bloodstream forms; DHAP, dihydroxyacetone phosphate; G3P, glyceraldehyde 3-phosphate; G6P, glucose 6-phosphate; Gly3P, glycerol 3-phosphate; PCF, procyclic form; PEP, phosphoenolpyruvate.
See this image and copyright information in PMC

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