doi: 10.1080/09553008514552861.
Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells
- PMID: 3485603
- DOI: 10.1080/09553008514552861
Item in Clipboard
Evidence for a general relationship between the induced level of DNA double-strand breakage and cell-killing after X-irradiation of mammalian cells
Int J Radiat Biol Relat Stud Phys Chem Med.
1986 Apr.
Abstract
X-ray-induced DNA double-strand breakage (dsb) and lethal lesion induction have been examined using normal and transformed fibroblasts of rodent and human origin. DNA dsb induction varied markedly among the different cell types and was found to reflect radiosensitivity. Linear relationships were found between DNA dsb and lethal lesion induction which were not significantly different for each cell type, suggesting a comparable probability of conversion of DNA dsb into a lethal lesion. The implications of these findings for models of cell survival are discussed.
Similar articles
-
The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation.Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Jul;48(1):45-54. doi: 10.1080/09553008514551051. Int J Radiat Biol Relat Stud Phys Chem Med. 1985. PMID: 3874180
-
Effect of radiomodifying agents on the ratios of X-ray-induced lesions in cellular DNA: use in lethal lesion determination.Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Apr;49(4):621-37. doi: 10.1080/09553008514552871. Int J Radiat Biol Relat Stud Phys Chem Med. 1986. PMID: 3485604
-
X-ray-induced DNA double-strand breaks as lethal lesions in diploid human fibroblasts compared to Chinese hamster ovary cells.Int J Radiat Biol. 1993 Mar;63(3):305-11. doi: 10.1080/09553009314550411. Int J Radiat Biol. 1993. PMID: 8095280
-
The dose-response for low-LET radiation-induced DNA double-strand breakage: methods of measurement and implications for radiation action models.Int J Radiat Biol. 1988 Jul;54(1):1-11. doi: 10.1080/09553008814551451. Int J Radiat Biol. 1988. PMID: 2899606 Review.
-
Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: a closer look.Biochimie. 1997 Oct;79(9-10):567-75. doi: 10.1016/s0300-9084(97)82005-6. Biochimie. 1997. PMID: 9466694 Review.
Cited by
-
Peripheral benzodiazepine receptors and glucose metabolism in human gliomas.J Neurooncol. 1994;22(1):15-22. doi: 10.1007/BF01058351. J Neurooncol. 1994. PMID: 7714547
-
Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.J Exp Clin Cancer Res. 2013 May 14;32(1):27. doi: 10.1186/1756-9966-32-27. J Exp Clin Cancer Res. 2013. PMID: 23672687 Free PMC article.
-
A link between double-strand break-related repair and V(D)J recombination: the scid mutation.Proc Natl Acad Sci U S A. 1991 May 15;88(10):4061-5. doi: 10.1073/pnas.88.10.4061. Proc Natl Acad Sci U S A. 1991. PMID: 1709732 Free PMC article.
-
Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy.Oncotarget. 2016 Apr 19;7(16):21469-83. doi: 10.18632/oncotarget.7412. Oncotarget. 2016. PMID: 26894978 Free PMC article.
-
Molecular markers of radiation-related normal tissue toxicity.Cancer Metastasis Rev. 2008 Sep;27(3):363-74. doi: 10.1007/s10555-008-9138-7. Cancer Metastasis Rev. 2008. PMID: 18506399 Free PMC article. Review.