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. 1986 Apr;49(4):639-43.
doi: 10.1080/09553008514552881.

A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis

A R Lehmann, C F Arlett, J F Burke, M H Green, M R James, J E Lowe

A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis

A R Lehmann et al. Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Apr.

Abstract

Ataxia-telangiectasia (A-T) cells are hypersensitive to the lethal effects of ionizing radiation and fail to inhibit DNA synthesis following radiation exposure. A cell line derived from an A-T line following DNA-mediated gene transfer has normal radiation sensitivity, but the kinetics of DNA synthesis after gamma-irradiation are similar to those of A-T cells.

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