Disconcerting and Counterintuitive Findings from a Trial of Exercise in Cystic Fibrosis: Can Exercise Make Our Patients Worse?

Affiliations

Editorial

Melanie Chin et al. Am J Respir Crit Care Med. 2022.

. 2022 Feb 1;205(3):269-270.

doi: 10.1164/rccm.202110-2446ED.

¹ The Ottawa Hospital Research Institute University of Ottawa Ottawa, Ontario, Canada.

No abstract available

Comment on

Effects of a Partially Supervised Conditioning Program in Cystic Fibrosis: An International Multicenter, Randomized Controlled Trial (ACTIVATE-CF).
Hebestreit H, Kriemler S, Schindler C, Stein L, Karila C, Urquhart DS, Orenstein DM, Lands LC, Schaeff J, Eber E, Radtke T; ACTIVATE-CF Study Working Group. Hebestreit H, et al. Am J Respir Crit Care Med. 2022 Feb 1;205(3):330-339. doi: 10.1164/rccm.202106-1419OC. Am J Respir Crit Care Med. 2022. PMID: 34735776 Free PMC article. Clinical Trial.

1. Button BM, Wilson C, Dentice R, Cox NS, Middleton A, Tannenbaum E, et al. Physiotherapy for cystic fibrosis in Australia and New Zealand: a clinical practice guideline. Respirology . 2016;21:656–657. - PMC - PubMed
1. Flume PA, Robinson KA, O’Sullivan BP, Finder JD, Vender RL, Willey-Courand D-B, et al. Cystic fibrosis pulmonary guidelines: airway clearance therapies. Respir Care . 2009;54:522–537. - PubMed
1. Radtke T, Nevitt SJ, Hebestreit H, Kriemler S. Physical exercise training for cystic fibrosis. Cochrane Database Syst Rev . 2017;11:CD002768. - PMC - PubMed
1. Hebestreit H, Kriemler S, Schindler C, Stein L, Karila C, Urquart DS, et al. Effects of a partially supervised conditioning program in cystic fibrosis: an international multicenter, randomized controlled trial (ACTIVATE-CF) Am J Respir Crit Care Med . 2022;205:330–339. - PMC - PubMed
1. Sawicki GS, Sellers DE, Robinson WM. High treatment burden in adults with cystic fibrosis: challenges to disease self-management. J Cyst Fibros . 2009;8:91–96. - PMC - PubMed