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Comment
. 2021 Dec 1;109(23):3713-3715.
doi: 10.1016/j.neuron.2021.11.006.

Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation

Aniket Bhattacharya  1 , M Chiara Manzini  2
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Unraveling the mysteries of MYT1L: From reprogramming factor to multifaceted regulator of neuronal differentiation

Aniket Bhattacharya et al. Neuron. .
Free article

Abstract

In this issue of Neuron, Chen et al. (2021) generated a mouse model for haploinsufficiency of MYT1L. MYT1L is widely used in neuronal reprogramming, and de novo mutations have been linked to a neurodevelopmental syndrome. Extensive characterization in this study better delineates MYT1L's role in transcriptional regulation and neuronal differentiation.

Keywords: Myt1l; autism; gene transcription; intellectual disability; neuronal development.

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