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. 2021 Dec 2;21(1):394.
doi: 10.1186/s12890-021-01764-4.

Results of the home mechanical ventilation national program among adults in Chile between 2008 and 2017

César Maquilón  1   2 , Mónica Antolini  3   4 , Nicolás Valdés  5 , Marianela Andrade  4 , Krishnna Canales  3   4 , Claudio Rabec  6 , Cristian Olave  4   7 , Miguel Aguayo  4 , Patricia Rivas  4 , Carmen Andrade  4 , Ángela Venegas  4 , Sandra Zapata  4 , María Elena Torres  4 , Osvaldo Cabrera  7 , Jorge Villalobos  4
Affiliations

Results of the home mechanical ventilation national program among adults in Chile between 2008 and 2017

César Maquilón et al. BMC Pulm Med. .

Abstract

Background: Home mechanical ventilation (HMV) is a viable and effective strategy for patients with chronic respiratory failure (CRF). The Chilean Ministry of Health started a program for adults in 2008.

Methods: This study examined the following data from a prospective cohort of patients with CRF admitted to the national HMV program: characteristics, mode of admission, quality of life, time in the program and survival.

Results: A total of 1105 patients were included. The median age was 59 years (44-58). Women accounted for 58.1% of the sample. The average body mass index (BMI) was 34.9 (26-46) kg/m2. A total of 76.2% of patients started HMV in the stable chronic mode, while 23.8% initiated HMV in the acute mode. A total of 99 patients were transferred from the children's program. There were 1047 patients on non-invasive ventilation and 58 patients on invasive ventilation. The median baseline PaCO2 level was 58.2 (52-65) mmHg. The device usage time was 7.3 h/d (5.8-8.8), and the time in HMV was 21.6 (12.2-49.5) months. The diagnoses were COPD (35%), obesity hypoventilation syndrome (OHS; 23.9%), neuromuscular disease (NMD; 16.3%), non-cystic fibrosis bronchiectasis or tuberculosis (non-CF BC or TBC; 8.3%), scoliosis (5.9%) and amyotrophic lateral sclerosis (ALS; 5.24%). The baseline score on the Severe Respiratory Insufficiency questionnaire (SRI) was 47 (± 17.9) points and significantly improved over time. The lowest 1- and 3-year survival rates were observed in the ALS group, and the lowest 9-year survival rate was observed in the non-CF BC or TB and COPD groups. The best survival rates at 9 years were OHS, scoliosis and NMD. In 2017, there were 701 patients in the children's program and 722 in the adult´s program, with a prevalence of 10.4 per 100,000 inhabitants.

Conclusion: The most common diagnoses were COPD and OHS. The best survival was observed in patients with OHS, scoliosis and NMD. The SRI score improved significantly in the follow-up of patients with HMV. The prevalence of HMV was 10.4 per 100,000 inhabitants. Trial registration This study was approved by and registered at the ethics committee of North Metropolitan Health Service of Santiago, Chile (N° 018/2021).

Keywords: Chronic respiratory failure; Domiciliary ventilation; Home mechanical ventilation; Long term ventilation; Obesity hypoventilation syndrome.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Annual flow of patients in home mechanical ventilation programs from 2008 to 2017 (n = 1105)
Fig. 2
Fig. 2
Yearly count of the cumulative population of patients treated with HMV (2008–2017)
Fig. 3
Fig. 3
Survival time in years for COPD patients categorized by BMI
Fig. 4
Fig. 4
SRI score at 0, 6, 12 and 36 months in patients treated with HMV
Fig. 5
Fig. 5
Survival time in years according to diagnostic groups
See this image and copyright information in PMC

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