Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;3(4):397-404.
doi: 10.1007/BF00165590.

Brain tumor protein synthesis and histological grades: a study by positron emission tomography (PET) with C11-L-Methionine

P Bustany, M Chatel, J M Derlon, F Darcel, P Sgouropoulos, F Soussaline, A Syrota

Brain tumor protein synthesis and histological grades: a study by positron emission tomography (PET) with C11-L-Methionine

P Bustany et al. J Neurooncol. 1986.

Abstract

Brain protein synthesis may be evaluated in vivo by a PET three compartment methionine model. 14 human brain tumor patients were studied. Protein synthesis rate (PSR) was increased in any glial tumor even in low grades, but this increase was statistically more important in anaplastic tumor. Radiotherapy action was evaluated in two patients. Local tumoral PSR was reduced to normal brain PSR after treatment. No difference was seen in normal cortex contralateral to the lesion between pre and post radiotherapy examination. 11 C-L-Methionine incorporation measured by PET looks as a very sensitive method for studying tumor metabolism and treatment effects.

PubMed Disclaimer

References

    1. Anal Biochem. 1982 Dec;127(2):372-5 - PubMed
    1. Ann Neurol. 1983 Dec;14 (6):614-26 - PubMed
    1. J Comput Assist Tomogr. 1980 Jun;4(3):285-90 - PubMed
    1. Arch Neurol. 1983 Oct;40(10 ):607-10 - PubMed
    1. Eur J Nucl Med. 1976;1(1):11-4 - PubMed

LinkOut - more resources