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. 2021 Oct;40(10):727-737.
doi: 10.1016/j.repce.2021.05.001. Epub 2021 Oct 28.

Safety and efficacy of balloon pulmonary angioplasty in a Portuguese pulmonary hypertension expert center

Rita Calé  1 , Filipa Ferreira  2 , Ana Rita Pereira  2 , Débora Repolho  2 , Daniel Sebaiti  2 , Sofia Alegria  2 , Sílvia Vitorino  2 , Pedro Santos  2 , Hélder Pereira  3 , Philippe Brenot  4 , Maria José Loureiro  2
Affiliations
Free article

Safety and efficacy of balloon pulmonary angioplasty in a Portuguese pulmonary hypertension expert center

Rita Calé et al. Rev Port Cardiol (Engl Ed). 2021 Oct.
Free article

Abstract

Introduction: Balloon pulmonary angioplasty (BPA) is an alternative therapy in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or residual/recurrent pulmonary hypertension (PH) after surgery. The aim of this study was to assess the short-term efficacy and safety of a BPA program.

Methods: This prospective single-center study included all BPA sessions performed in CTEPH patients between 2017 and 2019. Clinical assessment including WHO functional class, plasma biomarkers, 6-min walk test (6MWT) and right heart catheterization was performed at baseline and six months after the last BPA session.

Results: A total of 57 BPA sessions were performed in 11 CTEPH patients (64% with inoperable disease, 82% under pulmonar vasodilator therapy). Nine patients completed both the BPA program and a minimum six-month follow-up period. There were significant improvements in WHO functional class (p=0.004) and 6MWT (mean increase of 42 m; p=0.050) and a trend for significant hemodynamic improvement: 25% decrease in mean pulmonary artery pressure (mPAP) (p=0.082) and 42% decrease in pulmonary vascular resistance (PVR) (p=0.056). In the group of patients with severely impaired hemodynamics (three patients with mPAP >40 mmHg), the reduction was significant: 51% in mPAP (p=0.013) and 67% in PVR (p=0.050). Prostacyclin analogs and long-term oxygen therapy were withdrawn in all patients. Minor complications were recorded in 25% of patients. There were no major complications or deaths.

Conclusions: A BPA strategy on top of pulmonary vasodilator therapy further improves symptoms, exercise capacity and hemodynamics with an acceptable risk-benefit ratio in patients with inoperable CTEPH or residual/recurrent PH after surgery.

Keywords: Angioplastia pulmonar por balão; Balloon pulmonary angioplasty; Chronic thromboembolic pulmonary hypertension; Hemodinâmica vascular pulmonar; Hipertensão pulmonar tromboembólica crónica; Pulmonary vascular hemodynamics.

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