Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov 30:10:20-25.
doi: 10.33393/jcb.2021.2327. eCollection 2021 Jan-Dec.

Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?

Stefan Erfurt  1 , Meike Hoffmeister  2 , Stefanie Oess  2 , Katharina Asmus  1 , Oliver Ritter  1 , Susann Patschan  1 , Daniel Patschan  1
Affiliations
Review

Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?

Stefan Erfurt et al. J Circ Biomark. .

Abstract

Interleukin-33 (IL-33), a member of the IL-1 family, is critically involved in the modulation of the activity of a diverse range of immunocompetent cells. Essential roles have been implicated in cardioprotection, in both innate and adaptive immune responses in mucosal organs, and in the maintenance of adipose tissue cells. Over the past 10 years, several studies evaluated the usability of IL-33 as a biomarker in diseases of inflammatory and noninflammatory origin. Our group is currently evaluating the predictive role of serum IL-33 in acute kidney injury (AKI). The aim of the article is to discuss selected studies on IL-33 in different diseases and its potential role as a biomarker molecule.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declare no conflict of interest.

References

    1. Schrezenmeier EV, Barasch J, Budde K, Westhoff T, Schmidt-Ott KM. Biomarkers in acute kidney injury—pathophysiological basis and clinical performance. Acta Physiologica (Oxford, England). 2016 - PMC - PubMed
    1. Huo W, Zhang K, Nie Z, Li Q, Jin F. Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury. Transplant Rev (Orlando). 2010;24(3):143–146. doi: 10.1016/j.trre.2010.02.002. PubMed - DOI - PubMed
    1. Shang W, Wang Z. The update of NGAL in acute kidney injury. Curr Protein Pept Sci. 2017;18(12):1211–1217. doi: 10.2174/1389203717666160909125004. PubMed - DOI - PubMed
    1. Fan W, Ankawi G, Zhang J et al. Current understanding and future directions in the application of TIMP-2 and IGFBP7 in AKI clinical practice. Clin Chem Lab Med. 2019;57(5):567–576. doi: 10.1515/cclm-2018-0776. PubMed - DOI - PubMed
    1. Nalesso F, Cattarin L, Gobbi L, Fragasso A, Garzotto F, Calò LA. Evaluating Nephrocheck® as a predictive tool for acute kidney injury. Int J Nephrol Renovasc Dis. 2020;13:85–96. doi: 10.2147/IJNRD.S198222. PubMed - DOI - PMC - PubMed

LinkOut - more resources