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. 2021 Dec 1;39(6):709-711.
doi: 10.7518/hxkq.2021.06.013.

Effect of the prophylactic use of antibiotics on wound infection after cleft lip surgery

[Article in English, Chinese]
Min Wu  1 , Zhi Bing Zhu  1 , Bing Shi  1 , Cai Xia Gong  1 , Yang Li  1
Affiliations

Effect of the prophylactic use of antibiotics on wound infection after cleft lip surgery

[Article in English, Chinese]
Min Wu et al. Hua Xi Kou Qiang Yi Xue Za Zhi. .

Abstract
in English, Chinese

Objectives: To study the effect of preoperative prophylactic use of antibiotics on wound infection in patients with cleft lip.

Methods: Aretrospective study was conducted on the clinical data of 1 361 patients who underwent one-stage cleft lip repair in the Department of Cleft Lip and Palate in West China Hospital of Stomatology, Sichuan University, from January 2015 to November 2018. The patients were divided into two groups according to whether prophylactic antibiotics were used or not. There were 594 patients in the prevention group, including 373 unilateral incomplete cleft lip (UICL) patients, 157 unilateral complete cleft lip (UCCL) patients, 25 bilateral incomplete cleft lip (BICL) patients, 39 bilateral complete cleft lip (BCCL) patients. There were 767 patients in the non-prophylactic group, including 482 UICL patients, 211 UCCL patients, 31 BICL patients, 43 BCCL patients. The relationship between preoperative and postoperative leukocyte count, preoperative and postoperative body temperature, and postoperative wound infection were compared between the two groups.

Results: No significant difference was observed in the leukocyte count and body temperature between both groups (P>0.05).

Conclusions: The preoperative prophylactic use of antibiotics has no significant effect on the incidence of postoperative infection in patients undergoing cleft lip repair.

目的: 研究术前预防性使用抗生素对唇裂术后患者伤口发生感染的影响。方法: 对2015年1月—2018年11月在四川大学华西口腔医院唇腭裂外科行一期唇裂修复术的1 361例患者的临床资料进行回顾性研究。将预防性使用抗生素和未预防性使用抗生素的患者分为两组。预防组594例患者，按裂隙类型分为单侧不完全型单纯唇裂（UICL）患者373例，单侧完全型单纯唇裂（UCCL）患者157例，双侧不完全型单纯唇裂（BICL）患者25例，双侧完全型单纯唇裂（BCCL）患者39例。未预防组767例患者，按裂隙类型分为UICL患者482例，UCCL患者211例，BICL患者31例，BCCL患者43例。比较两组术前术后白细胞计数和体温与术后切口感染的关系。结果: 两组患者术前术后白细胞计数、体温相比差异均无统计学意义（P>0.05）。结论: 术前患者预防性使用抗生素对唇裂修复术后感染的发生无明显影响。.

Keywords: antibiotics; cleft lip; wound infection.

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Conflict of interest statement

利益冲突声明：作者声明本文无利益冲突。

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References

    1. 周 婷, 王 同海. Milard法和Tennison法修复单侧完全性唇裂316例比较研究[J] 中国美容医学. 2014;23(9):722–725.
    2. Zhou T, Wang TH. Milard technique and Tennison technique for primary repair of unilateral complete cleft lip: a comparative study on outcomes in 316 patients[J] Chin J Aesthet Med. 2014;23(9):722–725.
    1. 许 红红, 刘 允香, 黄 婉锋. 加强护理管理工作对预防医院感染的作用[J] 齐鲁护理杂志. 2012;18(3):89–90.
    2. Xu HH, Liu YX, Huang WF. Effect of strengthening nursing management on preventing hospital infection[J] J Qilu Nurs. 2012;18(3):89–90.
    1. Mangram AJ, Horan TC, Pearson ML, et al. Guide line for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee[J] Infect Control Hosp Epidemiol. 1999;20(4):250–278. - PubMed
    1. 刘 桂良, 王 继红, 王 涛. 唇腭裂手术期预防性应用抗生素必要性的探讨[J] 药学与临床研究. 2010;18(4):381–382.
    2. Liu GL, Wang JH, Wang T. A study on the necessority of pre-operational antibiotic prophylaxis in cleft lip and palate patients[J] Pharm Clin Res. 2010;18(4):381–382.
    1. 穆 玥, 陈 仁吉, 刘 洪涛, et al. 唇裂患儿围手术期抗生素应用的研究[J] 北京口腔医学. 2015;23(6):343–345.
    2. Mu Y, Chen RJ, Liu HT, et al. Investigation of perioperative application of antibiotics in cleft lip surgery[J] Beijing J Stomatol. 2015;23(6):343–345.

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