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Comment
. 2021 Dec 3;6(66):eabm1201.
doi: 10.1126/sciimmunol.abm1201. Epub 2021 Dec 3.

Move over NAIP, DDX17 diversifies the NLRC4 inflammasome

Katherine C Barnett  1   2 , Kaixin Liang  1   2   3 , Jenny P-Y Ting  1   2   4
Affiliations
Comment

Move over NAIP, DDX17 diversifies the NLRC4 inflammasome

Katherine C Barnett et al. Sci Immunol. .

Abstract

DDX17 binds short interspersed nuclear element RNAs to nucleate a dual NLRC4/NLRP3 inflammasome, highlighting the emerging role of endogenous ligands in NLRC4 activation (see the related Research Article by Wang et al.).

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  • DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.
    Wang SB, Narendran S, Hirahara S, Varshney A, Pereira F, Apicella I, Ambati M, Ambati VL, Yerramothu P, Ambati K, Nagasaka Y, Argyle D, Huang P, Baker KL, Marion KM, Gupta K, Liu B, Hinton DR, Canna SW, Sallam T, Sadda SR, Kerur N, Gelfand BD, Ambati J. Wang SB, et al. Sci Immunol. 2021 Dec 3;6(66):eabi4493. doi: 10.1126/sciimmunol.abi4493. Epub 2021 Dec 3. Sci Immunol. 2021. PMID: 34860583 Free PMC article.

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