Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Feb;63(2):395-401.

Idiotypes on antibodies to the La (SS-B) antigen are restricted and associated with the antigen binding site

A C Horsfall, P J Venables, P A Mumford, R N Maini

Idiotypes on antibodies to the La (SS-B) antigen are restricted and associated with the antigen binding site

A C Horsfall et al. Clin Exp Immunol. 1986 Feb.

Abstract

Rabbit anti-idiotypic antibodies were prepared against affinity purified autoantibodies to the ribonucleoprotein La (SS-B) antigen from the sera of three unrelated patients. Each anti-idiotype recognized private idiotypes expressed only on the immunizing anti-La antibody. In each case they were conformationally dependent and related to the antigen binding site. This demonstration of immunodominant private idiotypes on human autoantibodies to ribonucleoproteins is in direct contrast to the cross-reactive idiotypes described on rheumatoid factors and autoantibodies to DNA. We discuss the possibility that anti-La antibodies, unlike anti-DNA, arise as a result of autoantigenic stimulation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Lancet. 1983 Oct 8;2(8354):824-6 - PubMed
    1. J Exp Med. 1983 Sep 1;158(3):718-30 - PubMed
    1. Clin Exp Immunol. 1984 Jul;57(1):33-40 - PubMed
    1. J Clin Lab Immunol. 1984 Sep;15(1):1-17 - PubMed
    1. Eur J Immunol. 1985 Apr;15(4):368-75 - PubMed

Publication types

LinkOut - more resources