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Comparative Study
. 1986 Feb;63(2):473-7.

Difference in the biological properties of the two forms of the fourth component of human complement (C4)

J A Schifferli, G Steiger, J P Paccaud, A G Sjöholm, G Hauptmann
Comparative Study

Difference in the biological properties of the two forms of the fourth component of human complement (C4)

J A Schifferli et al. Clin Exp Immunol. 1986 Feb.

Abstract

The two forms of human C4 were compared in their haemolytic activity and in their capacity to mediate inhibition of immune complex precipitation in human C4 deficient sera. Whereas haemolysis by C4B was 3.2 fold more efficient than by C4A, C4A was 1.7 fold more efficient at inhibiting immune precipitation than C4B. Thus the biological properties of the two forms of human C4 are different and it is suggested that C4A is mainly involved in immune complex clearance reactions.

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References

    1. Immunochemistry. 1965 Sep;2(3):235-54 - PubMed
    1. Clin Exp Immunol. 1985 Jun;60(3):605-12 - PubMed
    1. J Immunol. 1974 Aug;113(2):574-83 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3576-80 - PubMed
    1. Clin Exp Immunol. 1980 Nov;42(2):387-94 - PubMed

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