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. 2014 Apr;30(2):69-72.
doi: 10.1177/8755122513520400. Epub 2014 Jan 10.

A Tale of Unequal Substitution: Minocycline and Acute Autoimmune Hepatitis

Dana H Manning  1 , Emily DeBuck  1 , Mallory Simchick  1
Affiliations

A Tale of Unequal Substitution: Minocycline and Acute Autoimmune Hepatitis

Dana H Manning et al. J Pharm Technol. 2014 Apr.

Abstract

Objective: In this case report, we describe the development of an acute autoimmune hepatitis associated with a short course of minocycline prescribed for a skin infection. Due to a drug shortage, minocycline was substituted for doxycycline. Conclusions: It is imperative that practitioners be aware of the different risks that accompany switching between drugs in the tetracycline class, particularly the risk of autoimmune conditions including hepatitis.

Keywords: autoimmune hepatitis; doxycycline; drug shortage; minocycline.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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